Krug, A., Cabanis, M., Pyka, M., Pauly, K., Kellermann, T., Walter, H., Wagner, M., Landsberg, M., Shah, N. J., Winterer, G., Woelwer, W., Brinkmeyer, J., Mueller, B. W., Kaergel, C., Wiedemann, G., Herrlich, J., Vogeley, K., Schilbach, L., Rapp, A., Klingberg, S. and Kircher, T. (2014). Attenuated prefrontal activation during decision-making under uncertainty in schizophrenia: A multi-center fMRI study. Schizophr. Res., 152 (1). S. 176 - 184. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1573-2509

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Abstract

Decisions are called decisions under uncertainty when either prior information is incomplete or the outcomes of the decision are unclear. Alterations in these processes related to decisions under uncertainty have been linked to delusions. In patients with schizophrenia, the underlying neural networks have only rarely been studied. We aimed to disentangle the neural correlates of decision-making and relate them to neuropsychological and psychopathological parameters in a large sample of patients with schizophrenia and healthy subjects. Fifty-seven patients and fifty-seven healthy volunteers from six centers had to either indicate via button-press from which of two bottles red or blue balls were drawn (decision-making under uncertainty condition), or indicate whether eight red balls had been presented (baseline condition) while BOLD signal was measured with fMRI. Patients based their decisions on less conclusive evidence and had decreased activations in the underlying neural network, comprising of medial and lateral frontal as well as parietal areas, as compared to healthy subjects. While current psychopathology was not correlated with brain activation, positive symptoms led to longer decision latencies in patients. These results suggest that decision-making under uncertainty in schizophrenia is affected by a complex interplay of aberrant neural activation. Furthermore, reduced neuropsychological functioning in patients was related to impaired decision-making and task performance was modulated by distinct positive symptoms. (C) 2013 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Krug, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabanis, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pyka, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pauly, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kellermann, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landsberg, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah, N. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winterer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woelwer, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brinkmeyer, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, B. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaergel, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiedemann, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herrlich, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogeley, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schilbach, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rapp, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingberg, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kircher, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-451265
DOI: 10.1016/j.schres.2013.11.007
Journal or Publication Title: Schizophr. Res.
Volume: 152
Number: 1
Page Range: S. 176 - 184
Date: 2014
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1573-2509
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEGATIVE-SYNDROME-SCALE; WORKING-MEMORY TASK; CONCLUSIONS BIAS; HEALTHY-INDIVIDUALS; BRAIN ACTIVATION; 5-FACTOR MODEL; PSYCHOSIS; PERFORMANCE; DELUSIONS; CORTEXMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/45126

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