Universität zu Köln

Moritz, Rose K. C., Ditschkowski, Markus, Klemke, Claus-Detlev, Terras, Sarah, Schlaak, Max, Knorr, Martin ORCID: 0000-0001-7236-4223, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Hegenbart, Ute, Kremens, Bernhard, Beelen, Dietrich W., Stuecker, Markus and Kreuter, Alexander (2014). Allogeneic stem cell transplantation in patients with aggressive primary cutaneous T-cell lymphoma - a case series of the ADF working group, cutaneous lymphomas. J. Dtsch. Dermatol. Ges., 12 (1). S. 39 - 48. HOBOKEN: WILEY-BLACKWELL. ISSN 1610-0387

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Abstract

Background: Allogeneic stem cell transplantation (alloSCT) is a treatment option for primary cutaneous T-cell lymphomas that may induce long-lasting complete remissions. Little information is available on safety and efficacy. Patients and methods: We retrospectively reviewed the data from patients with primary cutaneous T-cell lymphoma treated in the Departments of Dermatology of the Universities of Bochum, Mannheim and Cologne who received subsequent alloSCT between 2005 and 2012. Results: Nine patients with aggressive primary cutaneous T-cell-lymphoma received alloSCT. With a follow-up of 14 to 36 months after transplantation, 4 patients are alive and in complete remission. Two patients had recurrent disease post-transplantation, which was successfully treated with donor lymphocyte infusions. Non-relapse mortality was observed in three patients in advanced disease stages within six months after alloSCT. One patient showed only partial remission and died of disease after 32 months and one patient died 26 months after alloSCT with cause of death unknown. Conclusions: This report documents the possible benefit of a graft-versus-lymphoma effect in primary cutaneous T-cell lymphoma, as has been observed for other T-cell malignancies and emphasizes that alloSCT warrants further studies in this setting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moritz, Rose K. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ditschkowski, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Klemke, Claus-Detlev UNSPECIFIED UNSPECIFIED UNSPECIFIED Terras, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Knorr, Martin UNSPECIFIED orcid.org/0000-0001-7236-4223 UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED Hegenbart, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Kremens, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Beelen, Dietrich W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuecker, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451377
DOI:	10.1111/ddg.12212_suppl
Journal or Publication Title:	J. Dtsch. Dermatol. Ges.
Volume:	12
Number:	1
Page Range:	S. 39 - 48
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1610-0387
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OF-CANCER EORTC; MYCOSIS-FUNGOIDES; SEZARY-SYNDROME; RETROSPECTIVE ANALYSIS; TASK-FORCE; CLASSIFICATION; GRAFT; PROPOSAL; ISCL Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45137