Universität zu Köln

Dieplinger, Georg, Ditt, Vanessa, Arns, Wolfgang, Huppertz, Andrea, Kisner, Tuelay, Hellmich, Martin, Bauerfeind, Ursula and Stippel, Dirk L. (2014). Impact of de novo donor-specific HLA antibodies detected by Luminex solid-phase assay after transplantation in a group of 88 consecutive living-donor renal transplantations. Transpl. Int., 27 (1). S. 60 - 69. HOBOKEN: WILEY-BLACKWELL. ISSN 1432-2277

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Abstract

De novo donor-specific HLA antibodies (DSA) after renal transplantation are known to be correlated with poor graft outcome and the development of acute and chronic rejection. Currently, data for the influence of de novo DSA in patient cohorts including only living-donor renal transplantations (LDRT) are limited. A consecutive cohort of 88 LDRT was tested for the occurrence of de novo DSA by utilizing the highly sensitive Luminex solid-phase assay for antibody detection. Data were analyzed for risk factors for de novo DSA development and correlated with acute rejection (AR) and graft function. Patients with de novo DSA [31 (35%)] showed a trend for inferior graft function [mean creatinine change (mg/dL/year) after the first year: 0.15 DSA (+) vs. 0.02 DSA (-) (P=0.10)] and a higher rate of AR episodes, especially in case of de novo DSA of both class I and II [6 (55%), (P=0.05)]. Antibody-mediated rejection (AMR) appeared in five patients and was significantly correlated with de novo DSA (P=0.05). Monitoring for de novo DSA after LDRT may help to identify patients at risk of declining renal function. Especially patients with simultaneous presence of de novo DSA class I and class II are at a high risk to suffer AR episodes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dieplinger, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Ditt, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Arns, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Huppertz, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Kisner, Tuelay UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauerfeind, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, Dirk L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-451598
DOI:	10.1111/tri.12207
Journal or Publication Title:	Transpl. Int.
Volume:	27
Number:	1
Page Range:	S. 60 - 69
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1432-2277
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-LEUKOCYTE ANTIGEN; CHRONIC REJECTION; KIDNEY-TRANSPLANTATION; ORGAN-TRANSPLANTATION; CLINICAL MANAGEMENT; HUMORAL THEORY; POSTTRANSPLANT; ASSOCIATION; TECHNOLOGY; ALLOGRAFTS Multiple languages Surgery; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45159