Universität zu Köln

Pai, Sandesh, Hafftlang, Maryam, Atongo, George, Nagel, Christoph, Niesel, Johanna, Botov, Svetlana, Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827, Yard, Benito and Schatzschneider, Ulrich (2014). New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe. Dalton Trans., 43 (23). S. 8664 - 8679. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-9234

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Abstract

Five manganese(I) tricarbonyl complexes of the general formulae [Mn(bpea(N=CHC6H4R))(CO)(3)]PF6 and [Mn(bpea(NHCH2C6H4R))(CO)(3)] PF6 based on the tridentate bis(pyrazolyl) ethylamine (bpea) ligand, each containing a pendant 4-substituted phenyl group with R = H, I, and C=C-H, were synthesized and fully characterized, including X-ray structure analysis for three compounds. All complexes are stable in the dark in aqueous buffer for an extended period of time. However, CO-release could be triggered by illumination at 365 nm, establishing these compounds as novel photoactivatable CO-releasing molecules (PhotoCORMs). The influence of the imine vs. amine group in the ligands on the electronic structure and the photophysical behavior was investigated with the aid of DFT and TDDFT calculations. Solution IR studies on selected compounds allowed identification of intermediates resulting from the photoreaction. Finally, light-induced CO release from a model compound was demonstrated both in PBS buffer and in vitro in human umbilical vein endothelial cells (HUVECs) using COP-1 as a fluorescent switch-on probe.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pai, Sandesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Hafftlang, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Atongo, George UNSPECIFIED UNSPECIFIED UNSPECIFIED Nagel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Niesel, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Botov, Svetlana UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED Yard, Benito UNSPECIFIED UNSPECIFIED UNSPECIFIED Schatzschneider, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452008
DOI:	10.1039/c4dt00254g
Journal or Publication Title:	Dalton Trans.
Volume:	43
Number:	23
Page Range:	S. 8664 - 8679
Date:	2014
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-9234
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOLECULES PHOTOCORMS; FLUORESCENT-PROBE; METAL-CARBONYLS; BUILDING-BLOCKS; VISIBLE-LIGHT; CO RELEASE; BASIS-SETS; LIGANDS; BORANOCARBONATE; NANOPARTICLES Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/45200