Universität zu Köln

Kolarova, Hana, Ambruzova, Barbora, Sindlerova, Lenka Svihalkova, Klinke, Anna and Kubala, Lukas ORCID: 0000-0002-7729-7338 (2014). Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions. Mediat. Inflamm., 2014. LONDON: HINDAWI LTD. ISSN 1466-1861

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Abstract

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kolarova, Hana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ambruzova, Barbora UNSPECIFIED UNSPECIFIED UNSPECIFIED Sindlerova, Lenka Svihalkova UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinke, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Kubala, Lukas UNSPECIFIED orcid.org/0000-0002-7729-7338 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452508
DOI:	10.1155/2014/694312
Journal or Publication Title:	Mediat. Inflamm.
Volume:	2014
Date:	2014
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1466-1861
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPARAN-SULFATE PROTEOGLYCANS; LEUCINE-RICH PROTEOGLYCANS; C-REACTIVE PROTEIN; CELL GLYCOCALYX; SEVOFLURANE INHALATION; EXTRACELLULAR-MATRIX; CAROTID-ARTERY; SURFACE-LAYER; DEPENDENT VASODILATION; VASCULAR-PERMEABILITY Multiple languages Cell Biology; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45250