Universität zu Köln

Ristau, Tina, Keane, Pearse A., Walsh, Alexander C., Engin, Alicia, Mokwa, Nils, Kirchhof, Bernd, Sadda, SriniVas R. and Liakopoulos, Sandra (2014). Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration. Ophthalmologica, 231 (1). S. 37 - 45. BASEL: KARGER. ISSN 1423-0267

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Abstract

Purpose: Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). Procedures: VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. Results: At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4, p < 0.001) and with decreased volume of the photoreceptor layer (PRL, R = -0.4, p < 0.01). At 1 year, lower VA correlated with decreased volume of the retina (R = -0.7, p < 0.001), outer nuclear layer (R = -0.6, p < 0.05) and PRL (R = -0.7, p < 0.001). Decrease in VA after 1 year correlated with a decrease in PRL (R = 0.4, p < 0.05). Conclusions: Quantitative analysis of SD-OCT revealed correlations between VA and retinal and subretinal morphological changes in NVAMD. Message: Atrophy of the outer retina is an important correlate for lower VA in NVAMD. (C) 2013 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ristau, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Keane, Pearse A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walsh, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engin, Alicia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mokwa, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Sadda, SriniVas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452617
DOI:	10.1159/000354551
Journal or Publication Title:	Ophthalmologica
Volume:	231
Number:	1
Page Range:	S. 37 - 45
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0267
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBFOVEAL CHOROIDAL NEOVASCULARIZATION; QUANTITATIVE SUBANALYSIS; RANIBIZUMAB; VERTEPORFIN; MORPHOLOGY; THERAPY; IMPACT Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45261