Universität zu Köln

Warner, Kathrin, Crispatzu, Giuliano, Al-Ghaili, Nabil, Weit, Nicole, Florou, Vaia, You, M. James, Newrzela, Sebastian and Herling, Marco (2013). Models for mature T-cell lymphomas-A critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts. Crit. Rev. Oncol./Hematol., 88 (3). S. 680 - 696. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-0461

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Abstract

Mature T-cell lymphomas/leukemias (MTCL) have been understudied lymphoid neoplasms that currently receive growing attention. Our historically rudimentary molecular understanding and dissatisfactory interventional success in this complex and for the most part poor-prognostic group of tumors is only slightly improving. A major limiting aspect in further progress in these rare neoplasms is the lack of suitable model systems that would substantially facilitate pathogenic studies and pre-clinical drug evaluations. Such representations of MTCL have thus far not been systematically appraised. We therefore provide an overview on existing models and point out their particular advantages and limitations in the context of the specific scientific questions. After addressing issues of species-specific differences and classifications, we summarize data on MTCL cell lines of human as well as murine origin, on murine strain predispositions to MTCL, on available models of genetically engineered mice, and on transplant systems. From an in-silico meta-analysis of available primary data of gene expression profiles on human MTCL we cross-reference genes reported to transform T-cells in mice and reflect on their general vs entity-restricted relevance and on target-promoter influences. Overall, we identify the urgent need for new models of higher fidelity to human MTCL with respect to their increasingly recognized diversity and to predictions of drug response. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Warner, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Crispatzu, Giuliano UNSPECIFIED UNSPECIFIED UNSPECIFIED Al-Ghaili, Nabil UNSPECIFIED UNSPECIFIED UNSPECIFIED Weit, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Florou, Vaia UNSPECIFIED UNSPECIFIED UNSPECIFIED You, M. James UNSPECIFIED UNSPECIFIED UNSPECIFIED Newrzela, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470702
DOI:	10.1016/j.critrevonc.2013.07.014
Journal or Publication Title:	Crit. Rev. Oncol./Hematol.
Volume:	88
Number:	3
Page Range:	S. 680 - 696
Date:	2013
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-0461
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRUS TYPE-I; ANTI-CCR4 MONOCLONAL-ANTIBODY; COMBINED IMMUNODEFICIENT MICE; BCL-2 FAMILY PROTEINS; MOUSE MODEL; TRANSGENIC MICE; PROLYMPHOCYTIC LEUKEMIA; ANAPLASTIC LYMPHOMA; SCID MICE; CHROMOSOMAL INSTABILITY Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47070