Universität zu Köln

Rudolph, Tanja K., Schaper, Neele, Klinke, Anna, Demir, Cagri, Goldmann, Britta, Lau, Denise, Koester, Ralf, Hellmich, Martin ORCID: 0000-0001-5174-928X, Meinertz, Thomas, Baldus, Stephan and Rudolph, Volker (2013). Liberation of vessel-adherent myeloperoxidase reflects plaque burden in patients with stable coronary artery disease. Atherosclerosis, 231 (2). S. 354 - 359. CLARE: ELSEVIER IRELAND LTD. ISSN 1879-1484

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Abstract

Objective: Myeloperoxidase (MPO) has emerged as an important pathophysiological determinant of inflammatory vascular artery disease. It is appreciated that vessel immobilized, rather than circulating, MPO is critical for the progression of atherosclerotic lesions. The objective of this study was to investigate whether vessel-immobilized MPO is associated with the extent of coronary plaque burden. Methods: MPO plasma levels were determined by ELISA before and after heparin-release of vessel-bound MPO, to study the relation between vascular MPO deposition and densitometrically assessed coronary plaque burden in 77 patients with stable coronary artery disease. Results: Patients with a low increase in MPO plasma levels upon heparinization had a significantly smaller total plaque area and volume (12.1[IR: 6.2-19.4] mm(2) vs. 19.8[IR:11.3-31.5] mm(2), p < 0.01; 27.8 [IR: 12.3-44.8]mm(3) vs. 55.2[IR: 24.2-87.5] mm(3), p < 0.05). Multivariable linear regression revealed that Delta MPO was independently associated with plaque area, and that Delta MPO increased with the number of affected vessels. Selective sampling confirmed the predominant role of coronary MPO deposition. Conclusion: Our data demonstrate that heparin-induced mobilization of vessel-bound MPO is closely linked to coronary plaque burden and thus further corroborate the evidence for the intimate involvement of this enzyme in vascular pathophysiology, as well as the importance of inflammation in atherosclerosis. (C) 2013 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rudolph, Tanja K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaper, Neele UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinke, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Demir, Cagri UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldmann, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Lau, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Koester, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED orcid.org/0000-0001-5174-928X UNSPECIFIED Meinertz, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470962
DOI:	10.1016/j.atherosclerosis.2013.09.016
Journal or Publication Title:	Atherosclerosis
Volume:	231
Number:	2
Page Range:	S. 354 - 359
Date:	2013
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1879-1484
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUTROPHIL ACTIVATION; PROGNOSTIC VALUE; ASSOCIATION; RISK; INFLAMMATION; PROTEINS Multiple languages Cardiac & Cardiovascular Systems; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47096