Universität zu Köln

Passon, Anna M., Drabik, Anna and Sawicki, Peter T. (2013). Quality scores do not predict discrepant statistical significances among meta-analyses on different targets of glycemic control in type 2 diabetes. J. Clin. Epidemiol., 66 (12). S. 1356 - 1367. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-5921

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Abstract

Objectives: To examine differences in conclusions, statistical significances, and quality of systematic reviews on preventive effects of different targets of blood glucose lowering on macrovascular events in patients with type 2 diabetes. Study Design and Setting: We searched MEDLINE, the Cochrane Database of Systematic Reviews, and Embase until October 15, 2011. Systematic reviews using meta-analyses to compare macrovascular events in patients with type 2 diabetes randomized to different therapeutic targets of blood glucose were eligible for inclusion in this study. Effect measures were extracted and quality was assessed by Overview Quality Assessment Questionnaire, Assessment of Multiple Systematic Reviews, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses. An additional checklist was used to control for completeness and suitability of included trials, correctness of data extraction, and choice of outcome parameters. Results: The 16 included systematic reviews were partially discrepant in statistical significances of reported outcome parameters. Twelve systematic reviews did not include available relevant trials and included eight systematic reviews that should not have been included according to the systematic review's aim and search strategies. Quality differed considerably among systematic reviews. Conclusion: Physicians, researchers, and policy makers should bear in mind that common quality assessment instruments are necessary but not sufficient to guarantee reliable results and conclusions obtained from meta-analyses. (C) 2013 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Passon, Anna M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drabik, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Sawicki, Peter T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-471184
DOI:	10.1016/j.jclinepi.2013.06.006
Journal or Publication Title:	J. Clin. Epidemiol.
Volume:	66
Number:	12
Page Range:	S. 1356 - 1367
Date:	2013
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-5921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSIVE GLUCOSE CONTROL; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SYSTEMATIC REVIEWS; MACROVASCULAR EVENTS; METABOLIC-CONTROL; CLINICAL-TRIAL; MELLITUS; INSULIN Multiple languages Health Care Sciences & Services; Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47118