Universität zu Köln

Hussain, Ashiq, Saraiva, Luis R. ORCID: 0000-0003-4079-0396, Ferrero, David M., Ahuja, Gaurav, Krishna, Venkatesh S., Liberles, Stephen D. and Korsching, Sigrun I. (2013). High-affinity olfactory receptor for the death-associated odor cadaverine. Proc. Natl. Acad. Sci. U. S. A., 110 (48). S. 19579 - 19585. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

Carrion smell is strongly repugnant to humans and triggers distinct innate behaviors in many other species. This smell is mainly carried by two small aliphatic diamines, putrescine and cadaverine, which are generated by bacterial decarboxylation of the basic amino acids ornithine and lysine. Depending on the species, these diamines may also serve as feeding attractants, oviposition attractants, or social cues. Behavioral responses to diamines have not been investigated in zebrafish, a powerful model system for studying vertebrate olfaction. Furthermore, olfactory receptors that detect cadaverine and putrescine have not been identified in any species so far. Here, we show robust olfactory-mediated avoidance behavior of zebrafish to cadaverine and related diamines, and concomitant activation of sparse olfactory sensory neurons by these diamines. The large majority of neurons activated by low concentrations of cadaverine expresses a particular olfactory receptor, trace amineassociated receptor 13c (TAAR13c). Structure-activity analysis indicates TAAR13c to be a general diamine sensor, with pronounced selectivity for odd chains of medium length. This receptor can also be activated by decaying fish extracts, a physiologically relevant source of diamines. The identification of a sensitive zebrafish olfactory receptor for these diamines provides a molecular basis for studying neural circuits connecting sensation, perception, and innate behavior.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hussain, Ashiq UNSPECIFIED UNSPECIFIED UNSPECIFIED Saraiva, Luis R. UNSPECIFIED orcid.org/0000-0003-4079-0396 UNSPECIFIED Ferrero, David M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahuja, Gaurav UNSPECIFIED UNSPECIFIED UNSPECIFIED Krishna, Venkatesh S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liberles, Stephen D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Korsching, Sigrun I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-471796
DOI:	10.1073/pnas.1318596110
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	110
Number:	48
Page Range:	S. 19579 - 19585
Date:	2013
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ZEBRAFISH; BULB; EXPRESSION; POLYAMINES; EPITHELIUM; NEURONS; SYSTEM; IDENTIFICATION; SENSITIVITY; LIGANDS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47179