Universität zu Köln

Kumari, Snehlata ORCID: 0000-0002-4971-3162, Bonnet, Marion C., Ulvmar, Maria H., Wolk, Kerstin, Karagianni, Niki, Witte, Ellen, Uthoff-Hachenberg, Claudia, Renauld, Jean-Christophe ORCID: 0000-0003-1736-2131, Kollias, George ORCID: 0000-0003-1867-3150, Toftgard, Rune, Sabat, Robert, Pasparakis, Manolis ORCID: 0000-0002-9870-0966 and Haase, Ingo (2013). Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice. Immunity, 39 (5). S. 899 - 912. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

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Abstract

Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays an essential role in the pathogenesis of psoriasis, but its mechanism of action remains poorly understood. Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-kappa B was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of transcription 3 (STAT3) signaling in keratinocytes. IL-24 was strongly expressed in human psoriatic epidermis, and pharmacological inhibition of NF-kappa B increased IL-24 expression in TNF-stimulated human primary keratinocytes, suggesting that this mechanism is relevant for human psoriasis. Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-kappa B, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kumari, Snehlata UNSPECIFIED orcid.org/0000-0002-4971-3162 UNSPECIFIED Bonnet, Marion C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulvmar, Maria H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolk, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Karagianni, Niki UNSPECIFIED UNSPECIFIED UNSPECIFIED Witte, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Uthoff-Hachenberg, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Renauld, Jean-Christophe UNSPECIFIED orcid.org/0000-0003-1736-2131 UNSPECIFIED Kollias, George UNSPECIFIED orcid.org/0000-0003-1867-3150 UNSPECIFIED Toftgard, Rune UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabat, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED Haase, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-471988
DOI:	10.1016/j.immuni.2013.10.009
Journal or Publication Title:	Immunity
Volume:	39
Number:	5
Page Range:	S. 899 - 912
Date:	2013
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4180
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOUSE MODEL; IN-VIVO; INTERLEUKIN (IL)-19; INNATE IMMUNITY; CELL-DEATH; DISEASE; IL-22; TNF; ACTIVATION; PROTEIN Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47198