Koehler, Karsten ORCID: 0000-0002-9618-2069, Thevis, Mario and Schaenzer, Wilhelm (2013). Meta-analysis: Effects of glycerol administration on plasma volume, haemoglobin, and haematocrit. Drug Test. Anal., 5 (11-12). S. 896 - 900. HOBOKEN: WILEY-BLACKWELL. ISSN 1942-7611

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Abstract

The use of glycerol in combination with excess fluid can be used to increase total body water. Because glycerol hyperhydration may also be misused to mask the effects of blood doping on doping-relevant parameters, namely haemoglobin and haematocrit, glycerol has been prohibited by the World Anti-Doping Agency since 2010. In order to test this rationale, the purpose of this meta-analysis was to quantify the effects of glycerol hyperhydration on plasma volume, haemoglobin, and haematocrit in comparison to administration of fluid only. Following a literature search, a total of seven studies was included and meta-analyses were performed separately for the effects on plasma volume (5 studies, total n=54) and on haemoglobin (6 studies, n=52) and haematocrit (6 studies, n=52). The meta-analysis revealed that the increase in plasma volume was 3.3% larger (95%-CI: 1.1-5.5%) after glycerol administration when compared to fluid only. Reductions in haemoglobin were 0.2g/dl (95%-CI: -0.3, 0.0) larger and there was no difference in the changes in haematocrit between glycerol and fluid administration (95%-CI: -0.7-0.8%). In comparison with other plasma-volume expanding agents, glycerol hyperhydration has a very limited potential in increasing plasma volume and altering doping-relevant blood parameters. Copyright (c) 2013 John Wiley & Sons, Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Koehler, KarstenUNSPECIFIEDorcid.org/0000-0002-9618-2069UNSPECIFIED
Thevis, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaenzer, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-472332
DOI: 10.1002/dta.1580
Journal or Publication Title: Drug Test. Anal.
Volume: 5
Number: 11-12
Page Range: S. 896 - 900
Date: 2013
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1942-7611
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INDUCED HYPERHYDRATION; BLOOD-VOLUME; PERFORMANCE; EXERCISE; TEMPERATURE; REHYDRATION; EXPANSION; RESPONSESMultiple languages
Biochemical Research Methods; Chemistry, Analytical; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47233

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