Universität zu Köln

Spanagel, Rainer, Durstewitz, Daniel, Hansson, Anita, Heinz, Andreas ORCID: 0000-0001-5405-9065, Kiefer, Falk, Koehr, Georg, Matthaeus, Franziska, Noethen, Markus M., Noori, Hamid R., Obermayer, Klaus, Rietschel, Marcella, Schloss, Patrick, Scholz, Henrike, Schumann, Gunter, Smolka, Michael ORCID: 0000-0001-5398-5569, Sommer, Wolfgang, Vengeliene, Valentina, Walter, Henrik ORCID: 0000-0002-9403-6121, Wurst, Wolfgang ORCID: 0000-0003-4422-7410, Zimmermann, Uli S., Smits, Yannick and Derks, Eske M. (2013). A systems medicine research approach for studying alcohol addiction. Addict. Biol., 18 (6). S. 883 - 897. HOBOKEN: WILEY. ISSN 1369-1600

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Abstract

According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health-care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics-information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann etal. ) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Spanagel, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Durstewitz, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansson, Anita UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, Andreas UNSPECIFIED orcid.org/0000-0001-5405-9065 UNSPECIFIED Kiefer, Falk UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehr, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaeus, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Noethen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Noori, Hamid R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermayer, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Rietschel, Marcella UNSPECIFIED UNSPECIFIED UNSPECIFIED Schloss, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumann, Gunter UNSPECIFIED UNSPECIFIED UNSPECIFIED Smolka, Michael UNSPECIFIED orcid.org/0000-0001-5398-5569 UNSPECIFIED Sommer, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Vengeliene, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Henrik UNSPECIFIED orcid.org/0000-0002-9403-6121 UNSPECIFIED Wurst, Wolfgang UNSPECIFIED orcid.org/0000-0003-4422-7410 UNSPECIFIED Zimmermann, Uli S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smits, Yannick UNSPECIFIED UNSPECIFIED UNSPECIFIED Derks, Eske M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-472457
DOI:	10.1111/adb.12109
Journal or Publication Title:	Addict. Biol.
Volume:	18
Number:	6
Page Range:	S. 883 - 897
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1369-1600
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENOME-WIDE ASSOCIATION; CORTICOTROPIN-RELEASING-FACTOR; OPIOID-RECEPTOR OPRM1; NALTREXONE RESPONSE; PREFRONTAL CORTEX; SEEKING BEHAVIOR; BRAIN-FUNCTION; ETHANOL INTAKE; GENE; DEPENDENCE Multiple languages Biochemistry & Molecular Biology; Substance Abuse Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47245