Fritschi, L., Erren, T. C., Glass, D. C., Girschik, J., Thomson, A. K., Saunders, C., Boyle, T., El-Zaemey, S., Rogers, P., Peters, S., Slevin, T., D'Orsogna, A., de Vocht, F., Vermeulen, R. and Heyworth, J. S. (2013). The association between different night shiftwork factors and breast cancer: a case-control study. Br. J. Cancer, 109 (9). S. 2472 - 2481. LONDON: NATURE PUBLISHING GROUP. ISSN 1532-1827

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Abstract

Background: Research on the possible association between shiftwork and breast cancer is complicated because there are many different shiftwork factors, which might be involved including: light at night, phase shift, sleep disruption and changes in lifestyle factors while on shiftwork (diet, physical activity, alcohol intake and low sun exposure). Methods: We conducted a population-based case-control study in Western Australia from 2009 to 2011 with 1205 incident breast cancer cases and 1789 frequency age-matched controls. A self-administered questionnaire was used to collect demographic, reproductive, and lifestyle factors and lifetime occupational history and a telephone interview was used to obtain further details about the shiftwork factors listed above. Results: A small increase in risk was suggested for those ever doing the graveyard shift (work between midnight and 0500 hours) and breast cancer (odds ratio (OR) 1.16, 95% confidence interval (CI) = 0.97-1.39). For phase shift, we found a 22% increase in breast cancer risk (OR 1.22, 95% CI = 1.01-1.47) with a statistically significant dose-response relationship (P = 0.04). For the other shiftwork factors, risks were marginally elevated and not statistically significant. Conclusion: We found some evidence that some of the factors involved in shiftwork may be associated with breast cancer but the ORs were low and there were inconsistencies in duration and dose-response relationships.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Fritschi, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erren, T. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glass, D. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Girschik, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomson, A. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saunders, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boyle, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Zaemey, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogers, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slevin, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Orsogna, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Vocht, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vermeulen, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heyworth, J. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-473810
DOI: 10.1038/bjc.2013.544
Journal or Publication Title: Br. J. Cancer
Volume: 109
Number: 9
Page Range: S. 2472 - 2481
Date: 2013
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1532-1827
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INDIVIDUAL-DIFFERENCES; URINARY MELATONIN; WORK; RISK; LIGHT; MECHANISMS; WOMEN; DISRUPTION; EXPOSUREMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47381

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