Universität zu Köln

Recks, Mascha S., Stormanns, Eva R., Bader, Jonas, Arnhold, Stefan, Addicks, Klaus and Kuerten, Stefanie (2013). Early axonal damage and progressive myelin pathology define the kinetics of CNS histopathology in a mouse model of multiple sclerosis. Clin. Immunol., 149 (1). S. 32 - 46. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1521-7035

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Abstract

Studies of MS histopathology are largely dependent on suitable animal models. While light microscopic analysis gives an overview of tissue pathology, it falls short in evaluating detailed changes in nerve fiber morphology. The ultrastructurat data presented here and obtained from studies of myelin oligodendrocyte glycoprotein (MOG):35-55-induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice delineate that axonal damage and myelin pathology follow different kinetics in the disease course. While myelin pathology accumulated with disease progression, axonal damage coincided with the initial clinical disease symptoms and remained stable over time. This pattern applied both to irreversible axolysis and early axonal pathology. Notably, these histopathotogical patterns were reflected by the normal-appearing white matter (NAWM), suggesting that the NAWM is also in an active neurodegenerative state. The data underline the need for neuroprotection in MS and suggest the MOG model as a highly valuable toot for the assessment of different therapeutic strategies. (C) 2013 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Recks, Mascha S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stormanns, Eva R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bader, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Arnhold, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-474729
DOI:	10.1016/j.clim.2013.06.004
Journal or Publication Title:	Clin. Immunol.
Volume:	149
Number:	1
Page Range:	S. 32 - 46
Date:	2013
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1521-7035
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; APPEARING WHITE-MATTER; OLIGODENDROCYTE GLYCOPROTEIN; SPINAL-CORD; METABOLIC RECOVERY; ANIMAL-MODELS; G-RATIO; MECHANISMS; INJURY; EAE Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47472