Universität zu Köln

Sasse, Stephanie, Rothe, Achim, Goergen, Helen, Eichenauer, Dennis A., Lohri, Andreas, Kreher, Stephan, Jaeger, Ulrich, Bangard, Christopher, Kuhnert, Georg, Boell, Boris, von Tresckow, Bastian and Engert, Andreas (2013). Brentuximab vedotin (SGN-35) in patients with transplant-naive relapsed/refractory Hodgkin lymphoma. Leuk. Lymphoma, 54 (10). S. 2144 - 2149. LONDON: INFORMA HEALTHCARE. ISSN 1042-8194

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Abstract

Only limited data are available on the role of brentuximab vedotin (SGN-35) in transplant-naive relapsed or refractory patients with Hodgkin lymphoma (HL). We thus retrospectively analyzed 14 patients with primary refractory or relapsed HL who were treated with brentuximab vedotin as single agent in a named patient program, who had not received prior high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) due to refractory disease (n = 9), comorbidity (n = 4) and unknown reasons (n = 1). Brentuximab vedotin resulted in an overall response rate of 71% (10/14) with five complete responses (CRs). Five of those patients with refractory disease and four patients with relevant comorbidity responded. Consolidating ASCT (n = 4) or allogeneic SCT (n = 1) was performed in five patients. Median progression-free survival (PFS) was 9 months and the median overall survival (OS) was not reached. These data indicate the therapeutic efficacy of brentuximab vedotin in chemotherapy-refractory transplant-naive patients with HL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sasse, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothe, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Goergen, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichenauer, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohri, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreher, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaeger, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Bangard, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhnert, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Boell, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED von Tresckow, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-474949
DOI:	10.3109/10428194.2013.775434
Journal or Publication Title:	Leuk. Lymphoma
Volume:	54
Number:	10
Page Range:	S. 2144 - 2149
Date:	2013
Publisher:	INFORMA HEALTHCARE
Place of Publication:	LONDON
ISSN:	1042-8194
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; INTENSITY; CHEMOTHERAPY; DISEASE Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47494