Universität zu Köln

von Reutern, Boris, Gruenecker, Barbara, Yousefi, Behrooz H., Henriksen, Gjermund, Czisch, Michael and Drzezga, Alexander (2013). Voxel-Based Analysis of Amyloid-Burden Measured with [C-11]PiB PET in a Double Transgenic Mouse Model of Alzheimer's Disease. Mol. Imaging. Biol., 15 (5). S. 576 - 585. NEW YORK: SPRINGER. ISSN 1860-2002

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Abstract

The purpose of this study is to validate the feasibility of a voxel-based analysis of in vivo amyloid-beta positron emission tomography (PET) imaging studies in transgenic mouse models of Alzheimer's disease. We performed [C-11]PiB PET imaging in 20 APP/PS1 mice and 16 age-matched controls, and histologically determined the individual amyloid-beta plaque load. Using SPM software, we performed a voxel-based group comparison plus a regression analysis between PiB retention and actual plaque load, both thresholded at p (FWE) < 0.05. In addition, we carried out an individual ROI analysis in every animal. The automated voxel-based group comparison allowed us to identify voxels with significantly increased PiB retention in the cortical and hippocampal regions in transgenic animals compared to controls. The voxel-based regression analysis revealed a significant association between this signal increase and the actual cerebral plaque load. The validity of these results was corroborated by the individual ROI-based analysis. Voxel-based analysis of in vivo amyloid-beta PET imaging studies in mouse models of Alzheimer's disease is feasible and allows studying the PiB retention patterns in whole brain maps. Furthermore, the selected approach in our study also allowed us to establish a quantitative relation between tracer retention and actual plaque pathology in the brain in a voxel-wise manner.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Reutern, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenecker, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Yousefi, Behrooz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Henriksen, Gjermund UNSPECIFIED UNSPECIFIED UNSPECIFIED Czisch, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475070
DOI:	10.1007/s11307-013-0625-z
Journal or Publication Title:	Mol. Imaging. Biol.
Volume:	15
Number:	5
Page Range:	S. 576 - 585
Date:	2013
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1860-2002
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; PITTSBURGH COMPOUND-B; RAT-BRAIN; STATISTICAL-ANALYSIS; GLUCOSE-METABOLISM; HARDERIAN GLANDS; BETA; BINDING; LIGAND Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47507