Universität zu Köln

Ceccarini, Jenny ORCID: 0000-0003-2774-9516, De Hert, Marc, Van Winkel, Ruud, Peuskens, Joseph, Bormans, Guy, Kranaster, Laura, Enning, Frank, Koethe, Dagmar ORCID: 0000-0002-8324-6756, Leweke, F. Markus ORCID: 0000-0002-8163-195X and Van Laere, Koen (2013). Increased ventral striatal CB1 receptor binding is related to negative symptoms in drug-free patients with schizophrenia. Neuroimage, 79. S. 304 - 313. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Increasing animal genetic, post-mortem and pharmacological evidence supports a role for the cerebral type 1 cannabinoid (CB1) receptor in the pathogenesis of schizophrenia (SCZ) and/or neural circuit dysfunctions responsible for its symptomatology. Moreover, since important interspecies differences are present in CB1 receptor expression, in vivo human data are of direct interest. We investigated an in vivo CB1 receptor expression in SCZ patients compared to healthy controls (CON), and in relation with psychopathological symptom severity using positron emission tomography (PET) and the selective high-affinity radioligand [F-18]MK-9470. A total of sixty-seven patients with SCZ, with (SCZ-T, n = 51) and without (SCZ-F, n = 16) antipsychotic treatment, and 12 age and gender-matched CON were investigated with [F-18]MK-9470 PET. Parametric modified standardized uptake value (mSUV) images, reflecting CB1 receptor binding, were compared and related to psychopathological symptoms. Compared to CON, there was a significant increase of CB1 receptor binding in SCZ patients in the nucleus accumbens, insula, cingulate cortex, inferior frontal cortex, parietal and mediotemporal lobe. Furthermore, in the SCZ-F group only, CB1 receptor binding was negatively correlated to negative symptoms and to depression scores, especially in the nucleus accumbens. Present findings strongly support that CB1 receptor binding is altered in the mesocorticolimbic circuitry of both SCZ-T and SCZ-F patients, especially in the nucleus accumbens. In SCZ-F patients, it is associated with negative symptoms and depression scores. (C) 2013 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ceccarini, Jenny UNSPECIFIED orcid.org/0000-0003-2774-9516 UNSPECIFIED De Hert, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Winkel, Ruud UNSPECIFIED UNSPECIFIED UNSPECIFIED Peuskens, Joseph UNSPECIFIED UNSPECIFIED UNSPECIFIED Bormans, Guy UNSPECIFIED UNSPECIFIED UNSPECIFIED Kranaster, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Enning, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Koethe, Dagmar UNSPECIFIED orcid.org/0000-0002-8324-6756 UNSPECIFIED Leweke, F. Markus UNSPECIFIED orcid.org/0000-0002-8163-195X UNSPECIFIED Van Laere, Koen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475456
DOI:	10.1016/j.neuroimage.2013.04.052
Journal or Publication Title:	Neuroimage
Volume:	79
Page Range:	S. 304 - 313
Date:	2013
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; ANTERIOR CINGULATE CORTEX; CANNABINOID CB1; CEREBROSPINAL-FLUID; ANANDAMIDE LEVELS; INVERSE AGONIST; SYNDROME SCALE; HUMAN BRAIN; PET TRACER; AVAILABILITY Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47545