Universität zu Köln

Weigt, Carmen, Hertrampf, Torsten, Kluxen, Felix M., Flenker, Ulrich, Huelsemann, Frank, Fritzemeier, Karl Heinrich and Diel, Patrick (2013). Molecular effects of ER alpha- and beta-selective agonists on regulation of energy homeostasis in obese female Wistar rats. Mol. Cell. Endocrinol., 377 (1-2). S. 147 - 159. CLARE: ELSEVIER IRELAND LTD. ISSN 0303-7207

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Abstract

The molecular mechanisms underlying the effects of selective ER subtype activation on lipogenesis, adipogenesis, lipid utilization and storage as well as glucose metabolism are currently largely unknown and were analyzed in female OVX Wistar rats on a high-fat diet. Rats received estradiol (E2), ER subtype-selective agonists (Alpha and Beta), and genistein (Gen) for 10 weeks. In adipose tissue, treatment with E2, Alpha, and Beta significantly decreased lipogenic (SREBP-1c, FAS) and adipogenic genes (LPL, PPAR gamma). In liver and skeletal muscle of E2-, Alpha-, Beta-, and Gen-treated animals, lipogenesis and triglyceride accumulation were significantly reduced. Increased hepatic and muscular PPAR gamma mRNA expression was observed in untreated, Beta- and Gen-treated animals, which correlates with increased hepatic glucose uptake. However, only untreated animals showed impaired insulin sensitivity compared to all other groups. Therefore, PPAR gamma up-regulation in untreated animals suggests a compensatory mechanism, probably due to increased triglyceride accumulation in non-adipose tissues. Beta- and Gen-treated animals may benefit from the anabolic potency of ER beta that ameliorates lipid and glucose utilization in muscle. Activation of either ER subtype reduces fat enrichment and improves insulin sensitivity. Depending on the investigated tissue, different molecular pathways seem to be involved. (c) 2013 Published by Elsevier Ireland Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weigt, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Hertrampf, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kluxen, Felix M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Flenker, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Huelsemann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritzemeier, Karl Heinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Diel, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476081
DOI:	10.1016/j.mce.2013.07.007
Journal or Publication Title:	Mol. Cell. Endocrinol.
Volume:	377
Number:	1-2
Page Range:	S. 147 - 159
Date:	2013
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0303-7207
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESTROGEN-RECEPTOR-ALPHA; PEROXISOME-PROLIFERATOR; GLUCOSE-HOMEOSTASIS; ADIPOSE-TISSUE; PHYTOESTROGEN GENISTEIN; QUANTITATIVE-ANALYSIS; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; DIETARY ISOFLAVONES; RESPONSE ELEMENT Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47608