Universität zu Köln

Rabe, E., Guex, J-J, Morrison, N., Ramelet, A-A, Schuller-Petrovic, S., Scuderi, A., Staelens, I. and Pannier, F. (2013). Treatment of chronic venous disease with flavonoids: recommendations for treatment and further studies. Phlebology, 28 (6). S. 308 - 320. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1758-1125

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Abstract

Objectives: A variety of studies have suggested that flavonoids are effective for the treatment of CVD. However, many questions remain about their mechanism of action and when, how, and for what signs and symptoms they should be used. Method: A panel of experts in CVDmet in Budapest, Hungary in December 2011 to discuss the current state of knowledge of CVD and the role of flavonoids in its treatment. The discussion was based on a literature search in the current databases. The goals of this paper are recommendations for further studies on the use of flavonoids in the treatment of CVD. Results: There is good evidence to recommend the use of flavonoids in the treatment of CVD. However, because of the poor quality of some older clinical trials, inadequate reporting, and insufficient information, much work is still needed to firmly establish their clinical efficacy and to determine when and how they should be employed. In particular, long-term randomized, placebo-controlled, double-blind studies are needed to establish the efficacy and safety of flavonoids. Additional studies are also needed to establish their mechanism of action, pharmacokinetics, toxicity, and cost-effectiveness. Conclusions: Aside from good evidence for the use of flavonoids in CVD further studies are indicated to establish long term treatment in this indication.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rabe, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guex, J-J UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrison, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramelet, A-A UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuller-Petrovic, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scuderi, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Staelens, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pannier, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476259
DOI:	10.1177/0268355512471929
Journal or Publication Title:	Phlebology
Volume:	28
Number:	6
Page Range:	S. 308 - 320
Date:	2013
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1758-1125
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; RED VINE LEAF; PATIENT-REPORTED OUTCOMES; FOLIA-VITIS-VINIFERAE; DAFLON 500 MG; DOUBLE-BLIND; AIR PLETHYSMOGRAPHY; CONSENSUS STATEMENT; STASIS DERMATITIS; LEG ULCERS Multiple languages Surgery; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47625