Universität zu Köln

Schneider, Andrea, Ruppert, Manuela, Hendrich, Oliver, Giang, Thomas, Ogueta, Maite ORCID: 0000-0002-4777-8317, Hampel, Stefanie ORCID: 0000-0001-8287-549X, Vollbach, Marvin, Bueschges, Ansgar and Scholz, Henrike (2012). Neuronal Basis of Innate Olfactory Attraction to Ethanol in Drosophila. PLoS One, 7 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

The decision to move towards a mating partner or a food source is essential for life. The mechanisms underlying these behaviors are not well understood. Here, we investigated the role of octopamine - the invertebrate analogue of noradrenaline - in innate olfactory attraction to ethanol. We confirmed that preference is caused via an olfactory stimulus by dissecting the function of the olfactory co-receptor Orco (formally known as OR83b). Orco function is not required for ethanol recognition per se, however it plays a role in context dependent recognition of ethanol. Odor-evoked ethanol preference requires the function of Tbh (Tyramine beta hydroxalyse), the rate-limiting enzyme of octopamine synthesis. In addition, neuronal activity in a subset of octopaminergic neurons is necessary for olfactory ethanol preference. Notably, a specific neuronal activation pattern of tyraminergic/octopaminergic neurons elicit preference and is therefore sufficient to induce preference. In contrast, dopamine dependent increase in locomotor activity is not sufficient for olfactory ethanol preference. Consistent with the role of noradrenaline in mammalian drug induced rewards, we provide evidence that in adult Drosophila the octopaminergic neurotransmitter functions as a reinforcer and that the molecular dissection of the innate attraction to ethanol uncovers the basic properties of a response selection system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schneider, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruppert, Manuela UNSPECIFIED UNSPECIFIED UNSPECIFIED Hendrich, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Giang, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ogueta, Maite UNSPECIFIED orcid.org/0000-0002-4777-8317 UNSPECIFIED Hampel, Stefanie UNSPECIFIED orcid.org/0000-0001-8287-549X UNSPECIFIED Vollbach, Marvin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Scholz, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476528
DOI:	10.1371/journal.pone.0052007
Journal or Publication Title:	PLoS One
Volume:	7
Number:	12
Date:	2012
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OCTOPAMINERGIC NEURONS; CENTRAL COMPLEX; FRUIT-FLY; MELANOGASTER; BEHAVIOR; FLIES; STIMULATION; MECHANISMS; DOPAMINE; TYRAMINE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47652