Universität zu Köln

Baer, Magdalena M., Palm, Wilhelm, Eaton, Suzanne ORCID: 0000-0002-8319-284X, Leptin, Maria and Affolter, Markus ORCID: 0000-0002-5171-0016 (2012). Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. J. Cell Sci., 125 (24). S. 6038 - 6049. CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 1477-9137

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Abstract

The Drosophila tracheal system is a useful model for dissecting the molecular mechanisms controlling the assembly and expansion of tubular organs. We have identified microsomal triacylglycerol transfer protein (MTP) as a new player involved in the lumen expansion in unicellular tubes. MTP is an endoplasmic reticulum resident protein that can transfer triglycerides and phospholipids between membranes in vitro. MTP lipid transfer activity is crucial for the assembly and secretion of apoB family lipoproteins, which are carriers of lipids between different tissues. Here we describe an unexpected role of MTP in tracheal development, which we postulate to be independent of its known function in lipoprotein secretion. We propose that, in tracheal cells, MTP is involved in regulation of de novo apical membrane delivery to the existing lumen and thus promotes proper expansion of the larval tracheal system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baer, Magdalena M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Palm, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Eaton, Suzanne UNSPECIFIED orcid.org/0000-0002-8319-284X UNSPECIFIED Leptin, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Affolter, Markus UNSPECIFIED orcid.org/0000-0002-5171-0016 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476558
DOI:	10.1242/jcs.110452
Journal or Publication Title:	J. Cell Sci.
Volume:	125
Number:	24
Page Range:	S. 6038 - 6049
Date:	2012
Publisher:	COMPANY BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9137
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRIGLYCERIDE TRANSFER PROTEIN; PHOSPHOLIPID TRANSFER ACTIVITY; APOLIPOPROTEIN-B; BRANCHING MORPHOGENESIS; TUBE MORPHOGENESIS; SECRETION; LIPOPROTEIN; TRANSPORT; INSIGHTS; BINDING Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47655