Steffens, Michael
ORCID: 0000-0002-6445-8593, Leu, Costin
ORCID: 0000-0003-0598-3301, Ruppert, Ann-Kathrin, Zara, Federico
ORCID: 0000-0001-9744-5222, Striano, Pasquale
ORCID: 0000-0002-6065-1476, Robbiano, Angela, Capovilla, Giuseppe, Tinuper, Paolo, Gambardella, Antonio
ORCID: 0000-0001-7384-3074, Bianchi, Amedeo, La Neve, Angela, Crichiutti, Giovanni, de Kovel, Carolien G. F., Trenite, Dorothee Kasteleijn-Nolst, de Haan, Gerrit-Jan
ORCID: 0000-0003-2373-9863, Lindhout, Dick
ORCID: 0000-0001-9580-624X, Gaus, Verena, Schmitz, Bettina, Janz, Dieter, Weber, Yvonne G., Becker, Felicitas, Lerche, Holger, Steinhoff, Bernhard J., Kleefuss-Lie, Ailing A., Kunz, Wolfram S.
ORCID: 0000-0003-1113-3493, Surges, Rainer
ORCID: 0000-0002-3177-8582, Elger, Christian E., Muhle, Hiltrud, von Spiczak, Sarah, Ostertag, Philipp, Helbig, Ingo
ORCID: 0000-0001-8486-0558, Stephani, Ulrich, Moller, Rikke S., Hjalgrim, Helle, Dibbens, Leanne M., Bellows, Susannah
ORCID: 0000-0003-1949-8489, Oliver, Karen, Mullen, Saul, Scheffer, Ingrid E., Berkovic, Samuel F., Everett, Kate V., Gardiner, Mark R., Marini, Carla, Guerrini, Renzo
ORCID: 0000-0002-7272-7079, Lehesjoki, Anna-Elina, Siren, Auli, Guipponi, Michel, Malafosse, Alain, Thomas, Pierre, Nabbout, Rima, Baulac, Stephanie
ORCID: 0000-0001-6430-4693, Leguern, Eric, Guerrero, Rosa
ORCID: 0000-0002-4138-4667, Serratosa, Jose M., Reif, Philipp S., Rosenow, Felix, Moerzinger, Martina, Feucht, Martha, Zimprich, Fritz
ORCID: 0000-0002-6998-5480, Kapser, Claudia, Schankin, Christoph J., Suls, Arvid
ORCID: 0000-0003-0328-198X, Smets, Katrin, De Jonghe, Peter, Jordanova, Albena
ORCID: 0000-0002-3833-3754, Caglayan, Hande, Yapici, Zuhal, Yalcin, Destina A., Baykan, Betul, Bebek, Nerses, Ozbek, Ugur
ORCID: 0000-0001-5319-0547, Gieger, Christian
ORCID: 0000-0001-6986-9554, Wichmann, Heinz-Erich, Balschun, Tobias, Ellinghaus, David
ORCID: 0000-0002-4332-6110, Franke, Andre
ORCID: 0000-0003-1530-5811, Meesters, Christian
ORCID: 0000-0003-2408-7588, Becker, Tim, Wienker, Thomas F., Hempelmann, Anne, Schulz, Herbert, Rueschendorf, Franz, Leber, Markus, Pauck, Steffen M., Trucks, Holger, Toliat, Mohammad R., Nuernberg, Peter, Avanzini, Giuliano, Koeleman, Bobby P. C. and Sander, Thomas
(2012).
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
Hum. Mol. Genet., 21 (24).
S. 5359 - 5373.
OXFORD:
OXFORD UNIV PRESS.
ISSN 0964-6906
Full text not available from this repository.
Abstract
Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3 and account for 2030 of all epilepsies. Despite their high heritability of 80, the genetic factors predisposing to GGEs remain elusive. To identify susceptibility variants shared across common GGE syndromes, we carried out a two-stage genome-wide association study (GWAS) including 3020 patients with GGEs and 3954 controls of European ancestry. To dissect out syndrome-related variants, we also explored two distinct GGE subgroups comprising 1434 patients with genetic absence epilepsies (GAEs) and 1134 patients with juvenile myoclonic epilepsy (JME). Joint Stage-1 and 2 analyses revealed genome-wide significant associations for GGEs at 2p16.1 (rs13026414, P-meta 2.5 10(9), OR[T] 0.81) and 17q21.32 (rs72823592, P-meta 9.3 10(9), OR[A] 0.77). The search for syndrome-related susceptibility alleles identified significant associations for GAEs at 2q22.3 (rs10496964, P-meta 9.1 10(9), OR[T] 0.68) and at 1q43 for JME (rs12059546, P-meta 4.1 10(8), OR[G] 1.42). Suggestive evidence for an association with GGEs was found in the region 2q24.3 (rs11890028, P-meta 4.0 10(6)) nearby the SCN1A gene, which is currently the gene with the largest number of known epilepsy-related mutations. The associated regions harbor high-ranking candidate genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32. Further replication efforts are necessary to elucidate whether these positional candidate genes contribute to the heritability of the common GGE syndromes.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Steffens, Michael | UNSPECIFIED | orcid.org/0000-0002-6445-8593 | UNSPECIFIED | Leu, Costin | UNSPECIFIED | orcid.org/0000-0003-0598-3301 | UNSPECIFIED | Ruppert, Ann-Kathrin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zara, Federico | UNSPECIFIED | orcid.org/0000-0001-9744-5222 | UNSPECIFIED | Striano, Pasquale | UNSPECIFIED | orcid.org/0000-0002-6065-1476 | UNSPECIFIED | Robbiano, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Capovilla, Giuseppe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tinuper, Paolo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gambardella, Antonio | UNSPECIFIED | orcid.org/0000-0001-7384-3074 | UNSPECIFIED | Bianchi, Amedeo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | La Neve, Angela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Crichiutti, Giovanni | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de Kovel, Carolien G. F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Trenite, Dorothee Kasteleijn-Nolst | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de Haan, Gerrit-Jan | UNSPECIFIED | orcid.org/0000-0003-2373-9863 | UNSPECIFIED | Lindhout, Dick | UNSPECIFIED | orcid.org/0000-0001-9580-624X | UNSPECIFIED | Gaus, Verena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmitz, Bettina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Janz, Dieter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Weber, Yvonne G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Becker, Felicitas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lerche, Holger | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Steinhoff, Bernhard J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kleefuss-Lie, Ailing A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kunz, Wolfram S. | UNSPECIFIED | orcid.org/0000-0003-1113-3493 | UNSPECIFIED | Surges, Rainer | UNSPECIFIED | orcid.org/0000-0002-3177-8582 | UNSPECIFIED | Elger, Christian E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muhle, Hiltrud | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | von Spiczak, Sarah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ostertag, Philipp | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Helbig, Ingo | UNSPECIFIED | orcid.org/0000-0001-8486-0558 | UNSPECIFIED | Stephani, Ulrich | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Moller, Rikke S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hjalgrim, Helle | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dibbens, Leanne M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bellows, Susannah | UNSPECIFIED | orcid.org/0000-0003-1949-8489 | UNSPECIFIED | Oliver, Karen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mullen, Saul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scheffer, Ingrid E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Berkovic, Samuel F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Everett, Kate V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gardiner, Mark R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marini, Carla | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guerrini, Renzo | UNSPECIFIED | orcid.org/0000-0002-7272-7079 | UNSPECIFIED | Lehesjoki, Anna-Elina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Siren, Auli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guipponi, Michel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Malafosse, Alain | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Thomas, Pierre | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nabbout, Rima | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Baulac, Stephanie | UNSPECIFIED | orcid.org/0000-0001-6430-4693 | UNSPECIFIED | Leguern, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guerrero, Rosa | UNSPECIFIED | orcid.org/0000-0002-4138-4667 | UNSPECIFIED | Serratosa, Jose M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reif, Philipp S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rosenow, Felix | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Moerzinger, Martina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Feucht, Martha | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zimprich, Fritz | UNSPECIFIED | orcid.org/0000-0002-6998-5480 | UNSPECIFIED | Kapser, Claudia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schankin, Christoph J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Suls, Arvid | UNSPECIFIED | orcid.org/0000-0003-0328-198X | UNSPECIFIED | Smets, Katrin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | De Jonghe, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jordanova, Albena | UNSPECIFIED | orcid.org/0000-0002-3833-3754 | UNSPECIFIED | Caglayan, Hande | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yapici, Zuhal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yalcin, Destina A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Baykan, Betul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bebek, Nerses | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ozbek, Ugur | UNSPECIFIED | orcid.org/0000-0001-5319-0547 | UNSPECIFIED | Gieger, Christian | UNSPECIFIED | orcid.org/0000-0001-6986-9554 | UNSPECIFIED | Wichmann, Heinz-Erich | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Balschun, Tobias | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ellinghaus, David | UNSPECIFIED | orcid.org/0000-0002-4332-6110 | UNSPECIFIED | Franke, Andre | UNSPECIFIED | orcid.org/0000-0003-1530-5811 | UNSPECIFIED | Meesters, Christian | UNSPECIFIED | orcid.org/0000-0003-2408-7588 | UNSPECIFIED | Becker, Tim | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wienker, Thomas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hempelmann, Anne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schulz, Herbert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rueschendorf, Franz | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Leber, Markus | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pauck, Steffen M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Trucks, Holger | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Toliat, Mohammad R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nuernberg, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Avanzini, Giuliano | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Koeleman, Bobby P. C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sander, Thomas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-476648 |
DOI: |
10.1093/hmg/dds373 |
Journal or Publication Title: |
Hum. Mol. Genet. |
Volume: |
21 |
Number: |
24 |
Page Range: |
S. 5359 - 5373 |
Date: |
2012 |
Publisher: |
OXFORD UNIV PRESS |
Place of Publication: |
OXFORD |
ISSN: |
0964-6906 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
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JUVENILE MYOCLONIC EPILEPSY; INDEPENDENT TESTS; SEIZURE TYPES; RISK; MECHANISMS; MUTATIONS; MICRODELETIONS; VISUALIZATION; ARCHITECTURE; REPLICATION | Multiple languages | Biochemistry & Molecular Biology; Genetics & Heredity | Multiple languages |
|
URI: |
http://kups.ub.uni-koeln.de/id/eprint/47664 |
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