Universität zu Köln

Jacobi, Christina, Kruse, Friedrich E. and Cursiefen, Claus (2012). Prospective, Randomized, Controlled Comparison of SYSTANE UD Eye Drops Versus VISINE INTENSIV 1% EDO Eye Drops for the Treatment of Moderate Dry Eye. J. Ocular Pharmacol. Ther., 28 (6). S. 598 - 604. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-7732

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Abstract

Purpose: The aim of this prospective, randomized, clinical, single-center study was to compare the safety and efficacy of 2 ocular surface lubricant eye drops: preservative-free hydroxypropyl (HP)-Guar (SYSTANE UD (R)) eye drops versus preservative-free Tamarindus indica seed polysaccharide (TSP) 1% (VISINE INTENSIV 1% EDO (R)) eye drops. Methods: Fifty-six eyes of 28 patients with moderate keratoconjunctivitis sicca (DEWS severity level 2) were enrolled in the trial. Patients were randomized for 2 treatment groups (SYSTANE UD eye drops vs. VISINE INTENSIV 1% EDO eye drops). The eye drops in both groups were applied 5 times per day for 3 months. Statistical analyses were performed using Statistica (TM) software (Mann-Whitney U-test and Wilcoxon test). P-Values <0.05 were considered significant. Results: After 3 months of treatment the patients of both groups had subjective benefit in the relief of symptoms of dry eye disease evaluated by the Ocular Surface Disease Index (OSDI) questionnaire score. Patients treated with HP-Guar and TSP showed improvements in tear film stability measured by tear break-up time (TBUT), which are statistically significant in the HP-Guar group (P = 0.02). Conclusions: The results of this clinical trial show improvements of symptoms and signs in patients with moderate dry eye after the consistent use of preservative-free HP-Guar and TSP lubricant eye drops. Both artificial tear formulations produce amelioration in tear film stability improving eye conditions and patient quality of life. HP-Guar seems to be slightly more effective in improving ocular surface protection by decreasing tear film evaporation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jacobi, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruse, Friedrich E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477637
DOI:	10.1089/jop.2012.0066
Journal or Publication Title:	J. Ocular Pharmacol. Ther.
Volume:	28
Number:	6
Page Range:	S. 598 - 604
Date:	2012
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1557-7732
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GELLABLE LUBRICANT EYE; TAMARIND-SEED POLYSACCHARIDE; OCULAR SURFACE DISEASE; TEAR FILM BREAKUP; HYDROXYPROPYL-GUAR; HP-GUAR; HYALURONIC-ACID; OPEN-LABEL; EVAPORATION; CLASSIFICATION Multiple languages Ophthalmology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47763