Universität zu Köln

Kornetka, Darius, Trammer, Martin and Zange, Jochen (2012). Evaluation of a mobile NMR sensor for determining skin layers and locally estimating the T-2eff relaxation time in the lower arm. Magn. Reson. Mat. Phys. Biol. Med., 25 (6). S. 455 - 467. NEW YORK: SPRINGER. ISSN 0968-5243

Full text not available from this repository.

Abstract

The nuclear magnetic resonance (NMR) mobile-universal-surface-explorer (MOUSE) was evaluated in a pilot study to determine its ability to detect physiological changes in human skin caused by physical or pharmacological interventions. The left lower arm skin thicknesses of ten male subjects were measured five times using a Profile NMR-MOUSEA (R) (H-1, 19 MHz) before and after a venous occlusion manoeuvre. In five of the subjects, the T-2eff relaxation times were derived from a bi-exponential fitting and were determined in the dermis and subcutis before and after applying a salve containing capsaicin. The dermis (including the epidermis) showed rather homogeneous signal amplitudes. The subcutis was characterised by higher and more variable amplitudes. The full-skin thickness values were affirmed by ultrasound imaging. The NMR profiles did not show significant skin swelling due to venous occlusion. In the dermis, capsaicin caused significant (p < 0.05) decreases in both components of T (2eff) (100 +/- A 19 ms-19 +/- A 10 ms; 9.5 +/- A 0.5 ms-7.2 +/- A 1.6 ms). In the subcutis, the T (2eff) was not affected. In principle, NMR-MOUSE profiles are capable of detecting skin structure. However, precise measurements are jeopardised by poor reproducibility, long acquisition times, and incompatibility between the geometries of the sensitive area of the instrument and the non-planar structure of the skin. In the dermis, T (2eff) contrast could be used to detect the changes in tissue composition caused by inflammatory reactions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kornetka, Darius UNSPECIFIED UNSPECIFIED UNSPECIFIED Trammer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zange, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477645
DOI:	10.1007/s10334-012-0317-8
Journal or Publication Title:	Magn. Reson. Mat. Phys. Biol. Med.
Volume:	25
Number:	6
Page Range:	S. 455 - 467
Date:	2012
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0968-5243
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEAR MAGNETIC-RESONANCE; MICROSCOPY; RESOLUTION; CAPSAICIN; TISSUE; EDEMA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47764