Universität zu Köln

Rybniker, Jan, Nowag, Angela, Janicki, Hanna, Demant, Kai, Hartmann, Pia and Buening, Hildegard (2012). Incorporation of Antigens into Viral Capsids Augments Immunogenicity of Adeno-Associated Virus Vector-Based Vaccines. J. Virol., 86 (24). S. 13800 - 13805. WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-5514

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Abstract

Genetic modification of adeno-associated virus (AAV) capsids has previously been exploited to redirect viral tropism. Here we demonstrate that engineering of AAV capsids as scaffolds for antigen display augments antigen-specific immunogenicity. Combining antigen display with vector-mediated overexpression resulted in a single-shot prime-boost vaccine. This new class of vaccines induced immune responses significantly faster and an IgG antibody pool of higher avidity than conventional vectors, highlighting the potency of capsid modification in vaccine development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rybniker, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Nowag, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Janicki, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Demant, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Buening, Hildegard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477737
DOI:	10.1128/JVI.01708-12
Journal or Publication Title:	J. Virol.
Volume:	86
Number:	24
Page Range:	S. 13800 - 13805
Date:	2012
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	1098-5514
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RELATIVE AFFINITY; GENE-TRANSFER; ANTIBODIES; PROTEIN Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47773