Universität zu Köln

Mikolajczak, S., Quante, G., Weissenborn, S., Wafaisade, A., Wieland, U., Lueers, J. C., Klussmann, J. P. and Beutner, D. (2012). The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosis. Eur. Arch. Oto-Rhino-Laryn., 269 (12). S. 2543 - 2549. NEW YORK: SPRINGER. ISSN 0937-4477

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Abstract

Cidofovir is an antiviral agent used in the therapy of recurrent respiratory papillomatosis (RRP). In this study, we hypothesized that cidofovir is effective in decreasing the viral load of human papillomavirus (HPV). We established a type specific real-time PCR and measured HPV DNA loads. The course of viral load of HPV types 6 and 11 after repeated applications of cidofovir intralesionally was compared to the clinical outcome using a modified Derkay score. In 6 of the 8 (75 %) patients, we detected HPV 6. In 2 (25 %) patients, we detected HPV 11. In all of the patients, the viral load and the modified Derkay score decreased significantly during the treatment. We conclude that viral load of HPV can be monitored using the technique described here. Cidofovir in combination with surgical debulking reduces the viral load in patients with RRP. Relapses of the symptoms cannot be avoided but might be delayed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mikolajczak, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quante, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weissenborn, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wafaisade, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieland, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lueers, J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477809
DOI:	10.1007/s00405-012-2103-7
Journal or Publication Title:	Eur. Arch. Oto-Rhino-Laryn.
Volume:	269
Number:	12
Page Range:	S. 2543 - 2549
Date:	2012
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0937-4477
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-PAPILLOMAVIRUS DNA; INTRALESIONAL CIDOFOVIR; RISK-FACTORS; CARCINOMA; DISEASE; CELLS Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47780