Universität zu Köln

Hope, W. W., Castagnola, E., Groll, A. H., Roilides, E., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., Bassetti, M., Bille, J., Cornely, O. A., Cuenca-Estrella, M., Donnelly, J. P., Garbino, J., Herbrecht, R., Jensen, H. E., Kullberg, B. J., Lass-Floerl, C., Lortholary, O., Meersseman, W., Petrikkos, G., Richardson, M. D., Verweij, P. E., Viscoli, C. and Ullmann, A. J. (2012). ESCMID* guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp. Clin. Microbiol. Infect., 18. S. 38 - 53. OXFORD: ELSEVIER SCI LTD. ISSN 1469-0691

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Abstract

Clin Microbiol Infect 2012; 18 (Suppl. 7): 3852 Abstract Invasive candidiasis (IC) is a relatively common syndrome in neonates and children and is associated with significant morbidity and mortality. These guidelines provide recommendations for the prevention and treatment of IC in neonates and children. Appropriate agents for the prevention of IC in neonates at high risk include fluconazole (A-I), nystatin (B-II) or lactoferrin +/- Lactobacillus (B-II). The treatment of IC in neonates is complicated by the high likelihood of disseminated disease, including the possibility of infection within the central nervous system. Amphotericin B deoxycholate (B-II), liposomal amphotericin B (B-II), amphotericin B lipid complex (ABLC) (C-II), fluconazole (B-II), micafungin (B-II) and caspofungin (C-II) can all be potentially used. Recommendations for the prevention of IC in children are largely extrapolated from studies performed in adults with concomitant pharmacokinetic data and models in children. For allogeneic HSCT recipients, fluconazole (A-I), voriconazole (A-I), micafungin (A-I), itraconazole (B-II) and posaconazole (B-II) can all be used. Similar recommendations are made for the prevention of IC in children in other risk groups. With several exceptions, recommendations for the treatment of IC in children are extrapolated from adult studies, with concomitant pharmacokinetic studies. Amphotericin B deoxycholate (C-I), liposomal amphotericin B (A-I), ABLC (B-II), micafungin (A-I), caspofungin (A-I), anidulafungin (B-II), fluconazole (B-I) and voriconazole (B-I) can all be used.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hope, W. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Castagnola, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Groll, A. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roilides, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Akova, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arendrup, M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arikan-Akdagli, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bassetti, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bille, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cuenca-Estrella, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Donnelly, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garbino, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbrecht, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, H. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kullberg, B. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lass-Floerl, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lortholary, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meersseman, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrikkos, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Richardson, M. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verweij, P. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Viscoli, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullmann, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-477860
DOI:	10.1111/1469-0691.12040
Journal or Publication Title:	Clin. Microbiol. Infect.
Volume:	18
Page Range:	S. 38 - 53
Date:	2012
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1469-0691
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIPOSOMAL AMPHOTERICIN-B; LOW-BIRTH-WEIGHT; EMPIRICAL ANTIFUNGAL THERAPY; ITRACONAZOLE ORAL SOLUTION; STEM-CELL TRANSPLANTATION; CRITICALLY-ILL PATIENTS; CARE-UNIT PATIENTS; FUNGAL-INFECTIONS; FLUCONAZOLE PROPHYLAXIS; PEDIATRIC-PATIENTS Multiple languages Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47786