Universität zu Köln

Mobascher, Arian, Warbrick, Tracy ORCID: 0000-0001-8619-9409, Brinkmeyer, Juergen, Musso, Francesco, Stoecker, Tony, Shah, N. Jon ORCID: 0000-0002-8151-6169 and Winterer, Georg (2012). Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI. Psychiatry Res. Neuroimaging, 204 (2-3). S. 168 - 178. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7506

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Abstract

Nicotine can have beneficial effects on attention performance and corresponding brain function in both schizophrenia patients and healthy controls, but it remains controversial whether nicotine affects brain function differentially in patients vs. controls. The effects of nicotine on brain activity elicited by attention-requiring oddball-type tasks have not been studied in schizophrenia patients. In this study we sought to investigate the impact of nicotine on the p300 evoked potential component and corresponding fMRI (functional magnetic resonance imaging) activation measures in schizophrenia patients and controls. Applying a double-blind, placebo-controlled cross-over design, the effects of 1 mg nasal nicotine on brain activity elicited by a visual oddball-type task in N=14 schizophrenia and N=15 control smokers were studied with simultaneous EEG-fMRI. EEG single trial amplitudes were used to inform the fMRI analysis. We found a nicotine-associated increase in P300-informed fMRI activation in schizophrenia patients and controls, mainly in the anterior cingulate and adjacent medial frontal cortex. No group differences in the response to nicotine were found. Remarkably, averaged EEG and fMRI activation measures considered in isolation were largely unaffected by nicotine. Taken together, the effects of nicotine on P300 amplitude-associated brain activation do not seem to be fundamentally different in schizophrenic smokers and healthy controls. (C) 2012 Published by Elsevier Ireland Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mobascher, Arian UNSPECIFIED UNSPECIFIED UNSPECIFIED Warbrick, Tracy UNSPECIFIED orcid.org/0000-0001-8619-9409 UNSPECIFIED Brinkmeyer, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Musso, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoecker, Tony UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED Winterer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-478328
DOI:	10.1016/j.pscychresns.2012.09.005
Journal or Publication Title:	Psychiatry Res. Neuroimaging
Volume:	204
Number:	2-3
Page Range:	S. 168 - 178
Date:	2012
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7506
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EVENT-RELATED POTENTIALS; VISUAL ODDBALL TASK; BRAIN-FUNCTION; INTRACEREBRAL POTENTIALS; FUNCTIONAL MRI; RARE TARGET; VISUOSPATIAL ATTENTION; TRANSDERMAL NICOTINE; BOLD RESPONSE; SMOKING Multiple languages Clinical Neurology; Neuroimaging; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47832