Universität zu Köln

Pjetri, Eneda ORCID: 0000-0003-1973-0284, de Haas, Ria, de Jong, Simone ORCID: 0000-0002-8002-7195, Gelegen, Cigdem, Oppelaar, Hugo, Verhagen, Linda A. W., Eijkemans, Marinus J. C., Adan, Roger A., Olivier, Berend and Kas, Martien J. ORCID: 0000-0002-4471-8618 (2012). Identifying Predictors of Activity Based Anorexia Susceptibility in Diverse Genetic Rodent Populations. PLoS One, 7 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Animal studies are very useful in detection of early disease indicators and in unravelling the pathophysiological processes underlying core psychiatric disorder phenotypes. Early indicators are critical for preventive and efficient treatment of progressive psychiatric disorders like anorexia nervosa. Comparable to physical hyperactivity observed in anorexia nervosa patients, in the activity-based anorexia rodent model, mice and rats express paradoxical high voluntary wheel running activity levels when food restricted. Eleven inbred mouse strains and outbred Wistar WU rats were exposed to the activity-based anorexia model in search of identifying susceptibility predictors. Body weight, food intake and wheel running activity levels of each individual mouse and rat were measured. Mouse strains and rats with high wheel running activity levels during food restriction exhibited accelerated body weight loss. Linear mixed models for repeated measures analysis showed that baseline wheel running activity levels preceding the scheduled food restriction phase strongly predicted activity-based anorexia susceptibility (mice: Beta = -0.0158 (+/- 0.003 SE), P<0.0001; rats: Beta = -0.0242 (+/- 0.004 SE), P<0.0001) compared to other baseline parameters. These results suggest that physical activity levels play an important role in activity-based anorexia susceptibility in different rodent species with genetically diverse background. These findings support previous retrospective studies on physical activity levels in anorexia nervosa patients and indicate that pre-morbid physical activity levels could reflect an early indicator for disease severity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pjetri, Eneda UNSPECIFIED orcid.org/0000-0003-1973-0284 UNSPECIFIED de Haas, Ria UNSPECIFIED UNSPECIFIED UNSPECIFIED de Jong, Simone UNSPECIFIED orcid.org/0000-0002-8002-7195 UNSPECIFIED Gelegen, Cigdem UNSPECIFIED UNSPECIFIED UNSPECIFIED Oppelaar, Hugo UNSPECIFIED UNSPECIFIED UNSPECIFIED Verhagen, Linda A. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eijkemans, Marinus J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adan, Roger A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Olivier, Berend UNSPECIFIED UNSPECIFIED UNSPECIFIED Kas, Martien J. UNSPECIFIED orcid.org/0000-0002-4471-8618 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-478338
DOI:	10.1371/journal.pone.0050453
Journal or Publication Title:	PLoS One
Volume:	7
Number:	11
Date:	2012
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESTRICTED FEEDING SCHEDULE; INBRED MOUSE STRAINS; EATING-DISORDERS; PHYSICAL-ACTIVITY; RISK-FACTORS; ACTIVITY LEVEL; SELF-STARVATION; BODY-WEIGHT; NERVOSA; EXERCISE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47833