Universität zu Köln

Connerth, Melanie, Tatsuta, Takashi, Haag, Mathias, Klecker, Till ORCID: 0000-0003-0149-042X, Westermann, Benedikt ORCID: 0000-0002-2991-1604 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2012). Intramitochondrial Transport of Phosphatidic Acid in Yeast by a Lipid Transfer Protein. Science, 338 (6108). S. 815 - 819. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 0036-8075

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Abstract

Mitochondria are dynamic organelles whose function depends on intramitochondrial phospholipid synthesis and the supply of membrane lipids from the endoplasmic reticulum. How phospholipids are transported to and in-between mitochondrial membranes remained unclear. We identified Ups1, a yeast member of a conserved family of intermembrane space proteins, as a lipid transfer protein that can shuttle phosphatidic acid between mitochondrial membranes. Lipid transfer required the dynamic assembly of Ups1 with Mdm35 and allowed conversion of phosphatidic acid to cardiolipin in the inner membrane. High cardiolipin concentrations prevented membrane dissociation of Ups1, leading to its proteolysis and inhibiting transport of phosphatidic acid and cardiolipin synthesis. Thus, intramitochondrial lipid trafficking may involve a regulatory feedback mechanism that limits the accumulation of cardiolipin in mitochondria.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Connerth, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Haag, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Klecker, Till UNSPECIFIED orcid.org/0000-0003-0149-042X UNSPECIFIED Westermann, Benedikt UNSPECIFIED orcid.org/0000-0002-2991-1604 UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479049
DOI:	10.1126/science.1225625
Journal or Publication Title:	Science
Volume:	338
Number:	6108
Page Range:	S. 815 - 819
Date:	2012
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	0036-8075
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SACCHAROMYCES-CEREVISIAE; CARDIOLIPIN BIOSYNTHESIS; MITOCHONDRIA; PHOSPHOLIPIDS; TRAFFICKING; UPS1P; SYNTHASE; BIOLOGY; TAM41 Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47904