Universität zu Köln

Schildgen, Verena, Lochl, Vincenza, Luesebrink, Jessica, Brockmann, Michael and Schildgen, Oliver ORCID: 0000-0003-4297-9627 (2012). Epidemiology of EML4-ALK translocations in a small, German non-small-cell lung cancer patient cohort. Pers. Med., 9 (8). S. 801 - 804. LONDON: FUTURE MEDICINE LTD. ISSN 1741-0541

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Abstract

Background: Fusions and translocations of the ALK gene are an important genetic marker in different types of cancer and are therapy relevant, especially in lung cancer, as they predict the patient's response to crizotinib therapy. Thereby, EML4-ALK is assumed to be the most frequent fusion of ALK in lung cancer, although ALK is known to be able to fuse with approximately 20 different genes. Patients & methods: Formalin-fixed paraffin-embedded lung tissue from non-small-cell lung cancer patients previously tested positive for EML4-ALK were reanalyzed with three different FISH probe systems that are commercially available. Results: We describe a short series of patients with ALK translocations in which a surprisingly high percentage (66%) of non-EML4-ALK fusions were identified in non-small-cell lung cancer despite an estimated low percentage (similar to 20%) of such translocations. Conclusion: Depending on the diagnostic method used, those patients could receive a false-negative diagnosis and would miss the chance to benefit from novel crizotinib therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Lochl, Vincenza UNSPECIFIED UNSPECIFIED UNSPECIFIED Luesebrink, Jessica UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479387
DOI:	10.2217/PME.12.94
Journal or Publication Title:	Pers. Med.
Volume:	9
Number:	8
Page Range:	S. 801 - 804
Date:	2012
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1741-0541
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47938