Universität zu Köln

Eichenauer, Dennis A. and Engert, Andreas (2012). Advances in the treatment of Hodgkin lymphoma. Int. J. Hematol., 96 (5). S. 535 - 544. TOKYO: SPRINGER JAPAN KK. ISSN 1865-3774

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Abstract

In the past decades, Hodgkin lymphoma (HL) has turned from an incurable disease to one with the most favorable prognosis among adult malignancies. This is due to the introduction of effective multi-agent chemotherapy and the optimization of radiation techniques. At present, 80-90 % of patients achieve long-term remission when receiving appropriate first-line treatment. Even in case of relapse, up to 50 % can be successfully salvaged with high-dose chemotherapy and autologous stem cell transplantation. Thus, current studies do not necessarily aim at increasing treatment efficacy but rather focus on a possible reduction of acute and late toxicity by decreasing treatment intensity if possible. One promising strategy to spare therapy in good-risk patients is early response-adapted treatment stratification according to the result of interim positron emission tomography. The evaluation of novel drugs and the optimization of treatment for elderly HL patients and those with nodular lymphocyte-predominant HL are further aspects that are currently being addressed in ongoing trials. This review will give an overview on more recent clinical trials and discuss possible future strategies for the treatment of HL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eichenauer, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479533
DOI:	10.1007/s12185-012-1199-2
Journal or Publication Title:	Int. J. Hematol.
Volume:	96
Number:	5
Page Range:	S. 535 - 544
Date:	2012
Publisher:	SPRINGER JAPAN KK
Place of Publication:	TOKYO
ISSN:	1865-3774
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVOLVED-FIELD RADIOTHERAPY; STEM-CELL TRANSPLANTATION; TERM-FOLLOW-UP; BRENTUXIMAB VEDOTIN; RETROSPECTIVE ANALYSIS; DOSE-INTENSIFICATION; ELDERLY-PATIENTS; FINAL ANALYSIS; PHASE-II; CHEMOTHERAPY Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47953