Universität zu Köln

Tass, Peter A., Qin, Li, Hauptmann, Christian, Dovero, Sandra, Bezard, Erwan ORCID: 0000-0002-0410-4638, Boraud, Thomas and Meissner, Wassilios G. (2012). Coordinated reset has sustained aftereffects in Parkinsonian monkeys. Ann. Neurol., 72 (5). S. 816 - 821. HOBOKEN: WILEY-BLACKWELL. ISSN 0364-5134

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Abstract

Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816820

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Qin, Li UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauptmann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Dovero, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Bezard, Erwan UNSPECIFIED orcid.org/0000-0002-0410-4638 UNSPECIFIED Boraud, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, Wassilios G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-480333
DOI:	10.1002/ana.23663
Journal or Publication Title:	Ann. Neurol.
Volume:	72
Number:	5
Page Range:	S. 816 - 821
Date:	2012
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	0364-5134
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; HIGH-FREQUENCY STIMULATION; SUBTHALAMIC NUCLEUS; INDUCED DYSKINESIA; MACAQUE MODEL; DISEASE; SYMPTOMS; REVERSAL Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48033