Universität zu Köln

von Brandenstein, Melanie, Richter, Claudia and Fries, Jochen W. U. (2012). MicroRNAs: Small but amazing, and their association with endothelin. Life Sci., 91 (13-14). S. 475 - 490. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1879-0631

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Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules involved in the expressional regulation of genes by inhibiting gene translation. MicroRNAs are recruited and incorporated into the miRISC, ribonucleoprotein complex, targeting specific mRNAs through mechanisms specific for a miRNA sequence. Here we review the biogenesis, regulation, and monitoring of miRNAs, as well as the current evidence for potential roles of miRNAs in human diseases associated with activation of the endothelin system. These diseases include cancer, kidney disease, cardiovascular diseases, inflammatory diseases, infectious diseases, and blood diseases, that may all be aggravated by aberrant miRNA expression. In this review we will also discuss regulatory mechanisms determining production of miRNA as well as measuring or targeting miRNAs as potential novel approaches for diagnosis and treatment. Targeting miRNAs possibly will allow one to detect diseases or to interfere with the progression of diseases associated with activation of the endothelin system. (c) 2012 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Brandenstein, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fries, Jochen W. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481009
DOI:	10.1016/j.lfs.2012.06.025
Journal or Publication Title:	Life Sci.
Volume:	91
Number:	13-14
Page Range:	S. 475 - 490
Date:	2012
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1879-0631
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPITHELIAL-MESENCHYMAL TRANSITION; IN-SITU HYBRIDIZATION; BONE MORPHOGENETIC PROTEIN; SMALL TEMPORAL RNAS; NUCLEAR EXPORT; CIRCULATING MICRORNAS; NEGATIVE REGULATOR; MIRNA BIOGENESIS; KIDNEY-DISEASE; MESSENGER-RNAS Multiple languages Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48100