Universität zu Köln

Bermudez, Maria A., Goebel, Carl and Schultz, Wolfram (2012). Sensitivity to Temporal Reward Structure in Amygdala Neurons. Curr. Biol., 22 (19). S. 1839 - 1845. CAMBRIDGE: CELL PRESS. ISSN 0960-9822

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Abstract

The time of reward and the temporal structure of reward occurrence fundamentally influence behavioral reinforcement and decision processes [1-11]. However, despite knowledge about timing in sensory and motor systems [12-17], we know little about temporal mechanisms of neuronal reward processing. In this experiment, visual stimuli predicted different instantaneous probabilities of reward occurrence that resulted in specific temporal reward structures. Licking behavior demonstrated that the animals had developed expectations for the time of reward that reflected the instantaneous reward probabilities. Neurons in the amygdala, a major component of the brain's reward system [18-29], showed two types of reward signal, both of which were sensitive to the expected time of reward. First, the time courses of anticipatory activity preceding reward delivery followed the specific instantaneous reward probabilities and thus paralleled the temporal reward structures. Second, the magnitudes of responses following reward delivery covaried with the instantaneous reward probabilities, reflecting the influence of temporal reward structures at the moment of reward delivery. In being sensitive to temporal reward structure, the reward signals of amygdala neurons reflected the temporally specific expectations of reward. The data demonstrate an active involvement of amygdala neurons in timing processes that are crucial for reward function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bermudez, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goebel, Carl UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultz, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481096
DOI:	10.1016/j.cub.2012.07.062
Journal or Publication Title:	Curr. Biol.
Volume:	22
Number:	19
Page Range:	S. 1839 - 1845
Date:	2012
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	0960-9822
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SCALAR EXPECTANCY-THEORY; BASOLATERAL AMYGDALA; PREFRONTAL CORTEX; PRIMATE AMYGDALA; REPRESENTATION; RESPONSES; STIMULI; MACAQUE; CHOICE; MEMORY Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48109