Ditsch, Nina, Mayr, Doris, Lenhard, Miriam, Strauss, Carolin, Vodermaier, Andrea, Gallwas, Julia, Stoeckl, Doris, Graeser, Monika, Weissenbacher, Tobias, Friese, Klaus and Jeschke, Udo ORCID: 0000-0003-2623-3235 (2012). Correlation of thyroid hormone, retinoid X, peroxisome proliferator-activated, vitamin D and oestrogen/progesterone receptors in breast carcinoma. Oncol. Lett., 4 (4). S. 665 - 672. ATHENS: SPANDIDOS PUBL LTD. ISSN 1792-1074

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Abstract

Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thyroid receptor (TR), retinoid X receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) in malignant breast tumour tissue samples. Patients diagnosed and treated for breast cancer between 1990 and 2000 were included. Receptor expression was detected by immunohistochemical staining. Correlation analyses for the expression of the receptors were performed for the clinical and histopathological data. The paraffin-embedded tissue from 82 breast cancer patients was available. The different steroid receptors showed varying results when correlated with known histopathological markers. TR alpha 2 demonstrated the most significant correlations with steroid hormone receptors. Significant correlations between the major isoforms of TR, and between RXR, PPAR and VDR, were demonstrated in the patient sample. The immunohistochemical association of these receptors may provide the first proof of an interaction on the molecular level. This assumption awaits confirmation in studies with larger cohorts.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ditsch, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayr, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenhard, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strauss, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vodermaier, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallwas, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoeckl, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graeser, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weissenbacher, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friese, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeschke, UdoUNSPECIFIEDorcid.org/0000-0003-2623-3235UNSPECIFIED
URN: urn:nbn:de:hbz:38-481976
DOI: 10.3892/ol.2012.799
Journal or Publication Title: Oncol. Lett.
Volume: 4
Number: 4
Page Range: S. 665 - 672
Date: 2012
Publisher: SPANDIDOS PUBL LTD
Place of Publication: ATHENS
ISSN: 1792-1074
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GAMMA PPAR-GAMMA; ESTROGEN-RECEPTOR; CANCER CELLS; 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR; RXR-ALPHA; EXPRESSION; PROGESTERONE; TRANSCRIPTION; HETERODIMERS; ASSOCIATIONMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48197

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