Universität zu Köln

Kreppel, Matthias, Eich, Hans-Theodor, Brueggenolte, Christian, Dreiseidler, Timo, Rothamel, Daniel, Drebber, Uta, Kuebler, Alexander, Zoeller, Joachim E. and Scheer, Martin (2012). Preoperative vs. postoperative radiochemotherapy in patients with N2 squamous cell carcinoma of the oral cavity. Oral Oncol., 48 (10). S. 1019 - 1025. AMSTERDAM: ELSEVIER. ISSN 1879-0593

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Abstract

Background: The aim of our study was to evaluate retrospectively whether neoadjuvant or adjuvant radiochemotherapy yields better survival for patients with N2-oral squamous cell carcinoma and to identify subgroups, which may benefit from one of the therapeutic settings. No studies have been carried out to investigate whether radiochemotherapy should be applied before or after surgery. Methods: In total, 151 patients with oral squamous cell carcinoma with N2-nodal-status were reviewed. Eighty five patients received neoadjuvant radiochemotherapy, 66 patients were treated with surgery and adjuvant radiochemotherapy. Overall survival was plotted by Kaplan-Meier analysis. Prognostic factors were identified through univariate and multivariate analysis. Results: Patients treated with neoadjuvant radiochemotherapy had a significantly improved 5-year survival in comparison to patients, who received adjuvant radiochemotherapy (46.3% vs. 27.4%, p = 0.035). A subgroup analysis by T-stage revealed that neoadjuvant and adjuvant radiochemotherapy yielded similar 5-year survival rates for patients with T2N2-tumors (42.3% vs. 41.2%, p = 0.871), whereas patients with T4bN2-tumors significantly benefitted from neoadjuvant treatment (37.3% vs. 9.7%, p = 0.019). Conclusions: Neoadjuvant radiochemotherapy is an effective treatment for patients with nodal status N2-oral squamous cell carcinoma, however prospective randomized trials are needed to confirm, which patients should be treated with neoadjuvant or adjuvant radiochemotherapy. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, Hans-Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggenolte, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreiseidler, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuebler, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481994
DOI:	10.1016/j.oraloncology.2012.04.001
Journal or Publication Title:	Oral Oncol.
Volume:	48
Number:	10
Page Range:	S. 1019 - 1025
Date:	2012
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1879-0593
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLUS RADICAL SURGERY; OROPHARYNGEAL CANCER; CONCOMITANT CHEMOTHERAPY; RADIATION-THERAPY; RANDOMIZED-TRIAL; SURGICAL MARGINS; ADVANCED HEAD; NECK; CISPLATIN; RESECTION Multiple languages Oncology; Dentistry, Oral Surgery & Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48199