Stevens, K. N., Garcia-Closas, M., Fredericksen, Z., Kosel, M., Pankratz, V. S., Hopper, J. L., Dite, G. S., Apicella, C., Southey, M. C., Schmidt, M. K., Broeks, A., Van 't Veer, L. J., Tollenaar, R. A. E. M., Fasching, P. A., Beckmann, M. W., Hein, A., Ekici, A. B., Johnson, N., Peto, J., Silva, I. dos Santos, Gibson, L., Sawyer, E., Tomlinson, I., Kerin, M. J., Chanock, S., Lissowska, J., Hunter, D. J., Hoover, R. N., Thomas, G. D., Milne, R. L., Perez, J. I. Arias, Gonzalez-Neira, A., Benitez, J., Burwinkel, B., Meindl, A., Schmutzler, R. K., Bartrar, C. R., Hamann, U., Ko, Y. D., Bruening, T., Chang-Claude, J., Hein, R., Wang-Gohrke, S., Doerk, T., Schuermann, P., Bremer, M., Hillemanns, P., Bogdanova, N., Zalutsky, J. V., Rogov, Y. I., Antonenkova, N., Lindblom, A., Margolin, S., Mannermaa, A., Kataja, V., Kosma, V-M, Hartikainen, J., Chenevix-Trench, G., Chen, X., Peterlongo, P., Bonanni, B., Bernard, L., Manoukian, S., Wang, X., Cerhan, J., Vachon, C. M., Olson, J., Giles, G. G., Baglietto, L., McLean, C. A., Severi, G., John, E. M., Miron, A., Winqvist, R., Pylkaes, K., Jukkola-Vuorinen, A., Grip, M., Andrulis, I., Knight, J. A., Glendon, G., Mulligan, A. M., Cox, A., Brock, I. W., Elliott, G., Cross, S. S., Pharoah, P. P., Dunning, A. M., Pooley, K. A., Humphreys, M. K., Wang, J., Kang, D., Yoo, K-Y, Noh, D-Y, Sangrajrang, S., Gabrieau, V., Brennan, P., Mckay, J., Anton-Culver, H., Ziogas, A., Couch, F. J. and Easton, D. F. (2011). Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk. Br. J. Cancer, 105 (12). S. 1934 - 1940. LONDON: NATURE PUBLISHING GROUP. ISSN 0007-0920

Full text not available from this repository.

Abstract

BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of this study was to evaluate the association between inherited variation in this oncogene and risk of breast cancer. METHODS: A single-nucleotide polymorphism from the PIK3CA locus that was associated with breast cancer in a study of Caucasian breast cancer cases and controls from the Mayo Clinic (MCBCS) was genotyped in 5436 cases and 5280 controls from the Cancer Genetic Markers of Susceptibility (CGEMS) study and in 30 949 cases and 29 788 controls from the Breast Cancer Association Consortium (BCAC). RESULTS: Rs1607237 was significantly associated with a decreased risk of breast cancer in MCBCS, CGEMS and all studies of white Europeans combined (odds ratio (OR) = 0.97, 95% confidence interval (CI) 0.95-0.99, P = 4.6 x 10(-3)), but did not reach significance in the BCAC replication study alone (OR = 0.98, 95% CI 0.96-1.01, P = 0.139). CONCLUSION: Common germline variation in PIK3CA does not have a strong influence on the risk of breast cancer British Journal of Cancer (2011) 105, 1934 - 1939. doi: 10.1038/bjc.2011.448 www.bjcancer.com Published online 27 October 2011 (C) 2011 Cancer Research UK

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stevens, K. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Closas, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fredericksen, Z.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pankratz, V. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, J. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dite, G. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apicella, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, M. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, M. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broeks, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van 't Veer, L. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tollenaar, R. A. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fasching, P. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekici, A. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silva, I. dos SantosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibson, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawyer, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomlinson, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerin, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chanock, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lissowska, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, D. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoover, R. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, G. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milne, R. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez, J. I. AriasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Neira, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burwinkel, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, R. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartrar, C. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamann, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ko, Y. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruening, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang-Claude, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hein, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang-Gohrke, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerk, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuermann, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bremer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillemanns, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogdanova, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zalutsky, J. V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogov, Y. I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonenkova, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindblom, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Margolin, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mannermaa, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kataja, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kosma, V-MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartikainen, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chenevix-Trench, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, X.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterlongo, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonanni, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernard, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manoukian, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, X.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cerhan, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vachon, C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olson, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giles, G. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baglietto, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McLean, C. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Severi, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miron, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winqvist, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pylkaes, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jukkola-Vuorinen, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grip, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knight, J. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glendon, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulligan, A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brock, I. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elliott, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cross, S. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, P. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pooley, K. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Humphreys, M. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kang, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yoo, K-YUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noh, D-YUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sangrajrang, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gabrieau, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mckay, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton-Culver, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziogas, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Couch, F. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, D. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-483610
DOI: 10.1038/bjc.2011.448
Journal or Publication Title: Br. J. Cancer
Volume: 105
Number: 12
Page Range: S. 1934 - 1940
Date: 2011
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 0007-0920
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PIK3CA MUTATIONS; POOR-PROGNOSIS; HIGH-FREQUENCY; PTEN LOSS; GENE; ASSOCIATION; CORRELATE; PATHWAY; OVARIANMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48361

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item