Moesges, R. and Heubach, C. P. (2011). What is the Evidence for Non-Antibiotic Drug Therapy of Rhinosinusitis? Laryngo-Rhino-Otol., 90 (12). S. 740 - 747. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8685

Full text not available from this repository.

Abstract

Background: The German AWMF-guideline for rhinosinusitis and nasal polyps is to be reassessed. By searching the literature for the reevaluation we investigate in this systematic review to what extent existing recommendations can be affirmed, have to be changed or if there are new recommendations to give. Material and Methods: We searched PUBMED, MEDLINE and other databases via MEDPILOT, and the Cochrane Central Register of Controlled Trials without limiting the publication date range. Relevant clinical trials identified by 2 reviewers out of the search results were assessed for their methodical quality using an extended Jadad scale. Datas were extracted and study design, therapy/application, control group and results were analysed. Furthermore, levels of evidence for the different therapeutics have been determined. Results: Out of 1 346 search results 227 potentially eligible trials were identified; for this review we considered only the 47 trials published since 01/2006. Former recommendations are mainly supported by the identified relevant publications and several Cochrane reviews published in the last years. Conclusions: Levels of evidence are Ia for topical and systemic corticosteroid therapy for acute and chronic rhinosinusitis. Additionally, there is evidence that the application of saline solutions is useful not only for chronic but also for acute rhinosinusitis. New therapy options are under examination, but there is not enough evidence for adding them to actual recommendations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Moesges, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heubach, C. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-484125
DOI: 10.1055/s-0031-1285922
Journal or Publication Title: Laryngo-Rhino-Otol.
Volume: 90
Number: 12
Page Range: S. 740 - 747
Date: 2011
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1438-8685
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FUROATE NASAL SPRAY; QUALITY-OF-LIFE; DOUBLE-BLIND; MOMETASONE FUROATE; MUCOCILIARY CLEARANCE; SALINE SOLUTIONS; GENE-EXPRESSION; THERMAL WATER; ORAL STEROIDS; LONG-TERMMultiple languages
OtorhinolaryngologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48412

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item