Hinney, Anke ORCID: 0000-0001-5659-0706, Scherag, Andre ORCID: 0000-0002-9406-4704, Jarick, Ivonne, Albayrak, Oezguer, Puetter, Carolin, Pechlivanis, Sonali, Dauvermann, Maria R., Beck, Sebastian, Weber, Heike ORCID: 0000-0002-9421-1292, Scherag, Susann, Nguyen, Trang T., Volckmar, Anna-Lena, Knoll, Nadja, Faraone, Stephen V., Neale, Benjamin M., Franke, Barbara ORCID: 0000-0003-4375-6572, Cichon, Sven ORCID: 0000-0002-9475-086X, Hoffmann, Per ORCID: 0000-0002-6573-983X, Noethen, Markus M., Schreiber, Stefan, Joeckel, Karl-Heinz, Wichmann, H. -Erich, Freitag, Christine, Lempp, Thomas, Meyer, Jobst, Gilsbach, Susanne, Herpertz-Dahlmann, Beate, Sinzig, Judith ORCID: 0000-0002-3693-3318, Lehmkuhl, Gerd, Renner, Tobias J., Warnke, Andreas, Romanos, Marcel ORCID: 0000-0001-7628-8299, Lesch, Klaus-Peter ORCID: 0000-0001-8348-153X, Reif, Andreas, Schimmelmann, Benno G. and Hebebrand, Johannes (2011). Genome-Wide Association Study in German Patients With Attention Deficit/Hyperactivity Disorder. Am. J. Med. Genet. B, 156B (8). S. 888 - 898. MALDEN: WILEY-BLACKWELL. ISSN 1552-4841

Full text not available from this repository.

Abstract

The heritability of attention deficit hyperactivity disorder (ADHD) is approximately 0.8. Despite several larger scale attempts, genome-wide association studies (GWAS) have not led to the identification of significant results. We performed a GWAS based on 495 German young patients with ADHD (according to DSM-IV criteria; Human660W-Quadv1; Illumina, San Diego, CA) and on 1,300 population-based adult controls (HumanHap550v3; Illumina). Some genes neighboring the single nucleotide polymorphisms (SNPs) with the lowest P-values (best P-value: 8.38 x 10(-7)) have potential relevance for ADHD (e. g., glutamate receptor, metabotropic 5 gene, GRM5). After quality control, the 30 independent SNPs with the lowest P-values (P-values <= 7.57 x 10(-5)) were chosen for confirmation. Genotyping of these SNPs in up to 320 independent German families comprising at least one child with ADHD revealed directionally consistent effect-size point estimates for 19 (10 not consistent) of the SNPs. In silico analyses of the 30 SNPs in the largest meta-analysis so far (2,064 trios, 896 cases, and 2,455 controls) revealed directionally consistent effect-size point estimates for 16 SNPs (11 not consistent). None of the combined analyses revealed a genome-wide significant result. SNPs in previously described autosomal candidate genes did not show significantly lower P-values compared to SNPs within random sets of genes of the same size. We did not find genome-wide significant results in a GWAS of German children with ADHD compared to controls. The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD. (C) 2011 Wiley Periodicals, Inc.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hinney, AnkeUNSPECIFIEDorcid.org/0000-0001-5659-0706UNSPECIFIED
Scherag, AndreUNSPECIFIEDorcid.org/0000-0002-9406-4704UNSPECIFIED
Jarick, IvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albayrak, OezguerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puetter, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pechlivanis, SonaliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dauvermann, Maria R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beck, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, HeikeUNSPECIFIEDorcid.org/0000-0002-9421-1292UNSPECIFIED
Scherag, SusannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen, Trang T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volckmar, Anna-LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoll, NadjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faraone, Stephen V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neale, Benjamin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, BarbaraUNSPECIFIEDorcid.org/0000-0003-4375-6572UNSPECIFIED
Cichon, SvenUNSPECIFIEDorcid.org/0000-0002-9475-086XUNSPECIFIED
Hoffmann, PerUNSPECIFIEDorcid.org/0000-0002-6573-983XUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreiber, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joeckel, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wichmann, H. -ErichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freitag, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lempp, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, JobstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilsbach, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herpertz-Dahlmann, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sinzig, JudithUNSPECIFIEDorcid.org/0000-0002-3693-3318UNSPECIFIED
Lehmkuhl, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renner, Tobias J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warnke, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Romanos, MarcelUNSPECIFIEDorcid.org/0000-0001-7628-8299UNSPECIFIED
Lesch, Klaus-PeterUNSPECIFIEDorcid.org/0000-0001-8348-153XUNSPECIFIED
Reif, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schimmelmann, Benno G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hebebrand, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-484640
DOI: 10.1002/ajmg.b.31246
Journal or Publication Title: Am. J. Med. Genet. B
Volume: 156B
Number: 8
Page Range: S. 888 - 898
Date: 2011
Publisher: WILEY-BLACKWELL
Place of Publication: MALDEN
ISSN: 1552-4841
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEFICIT HYPERACTIVITY DISORDER; RESTLESS-LEGS-SYNDROME; MOLECULAR-GENETICS; BIPOLAR DISORDER; COMMON VARIANTS; ADHD; LINKAGE; GENES; METAANALYSIS; LOCIMultiple languages
Genetics & Heredity; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48464

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item