Dieude, P., Bouaziz, M., Guedj, M., Riemekasten, G., Airo, P., Mueller, M., Cusi, D., Matucci-Cerinic, M., Melchers, I., Koenig, W., Salvi, E., Wichmann, H. E., Cuomo, G., Hachulla, E., Diot, E., Hunzelmann, N., Caramaschi, P., Mouthon, L., Riccieri, V., Distler, J., Tarner, I., Avouac, J., Meyer, O., Kahan, A., Chiocchia, G., Boileau, C. and Allanore, Y. (2011). Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: Association with the functional IRAK1 196Phe/532Ser haplotype. Arthritis Rheum., 63 (12). S. 3979 - 3988. HOBOKEN: WILEY. ISSN 1529-0131

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Abstract

Objective Several autoimmune disorders, including systemic sclerosis (SSc), are characterized by a strong sex bias. To date, it is not known whether genes on the sex chromosomes influence SSc susceptibility. Recently, an IRAK1 haplotype that contains the 196Phe functional variant (rs1059702), located on Xq28, was found to confer susceptibility to systemic lupus erythematosus (SLE). This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype. Methods. We tested for an association with the IRAK1 SLE risk haplotype in a discovery set of 849 SSc patients and 625 controls. IRAK1 rs1059702 was further genotyped in a replication set, which included Caucasian women from Italy (493 SSc patients and 509 controls) and Germany (466 SSc patients and 1,083 controls). Results. An association between the IRAK1 haplotype and SSc was detected in the discovery set. In both the discovery and replication sets, the rs1059702 TT genotype was found to be associated with specific SSc subsets, highlighting a potential contribution to disease severity. A meta-analysis provided evidence of an association of both the T allele and TT genotype with the overall disease, with an odds ratio (OR) of 1.20 and 95% confidence interval (95% CI) of 1.06- 1.35 for the T allele (P = 0.003) and an OR of 1.49 and 95% CI of 1.06- 2.10 for the TT genotype (P = 0.023). However, the most notable associations were observed with the diffuse cutaneous, anti- topoisomerase I antibody positive, and SSc-related fibrosing alveolitis subsets (OR 2.35 [95% CI 1.51- 3.66], P = 1.56 x 10(-4), OR 2.84 [95% CI 1.87- 4.32], P = 1.07 x 10(-6), and OR 2.09 [95% CI 1.35- 3.24], P = 9.05 x 10(-4), respectively). Conclusion. Our study provides the first evidence of an association between IRAK1 and SSc, demonstrating that a sex chromosome gene directly influences SSc susceptibility and its phenotypic heterogeneity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dieude, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bouaziz, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guedj, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemekasten, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airo, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cusi, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matucci-Cerinic, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melchers, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvi, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wichmann, H. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuomo, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hachulla, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diot, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunzelmann, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caramaschi, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mouthon, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riccieri, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tarner, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Avouac, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahan, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chiocchia, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boileau, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allanore, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-484682
DOI: 10.1002/art.30640
Journal or Publication Title: Arthritis Rheum.
Volume: 63
Number: 12
Page Range: S. 3979 - 3988
Date: 2011
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1529-0131
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENETIC RISK-FACTOR; NF-KAPPA-B; LUPUS-ERYTHEMATOSUS; INNATE-IMMUNITY; DISEASE; SCLERODERMA; ACTIVATION; VARIANT; IRF5; PATHOGENESISMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48468

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