Universität zu Köln

Schiffels, Stephan ORCID: 0000-0002-1017-9150, Szoellosi, Gergely J., Mustonen, Ville ORCID: 0000-0002-7270-1792 and Laessig, Michael (2011). Emergent Neutrality in Adaptive Asexual Evolution. Genetics, 189 (4). S. 1361 - 1390. BETHESDA: GENETICS SOCIETY AMERICA. ISSN 1943-2631

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Abstract

In nonrecombining genomes, genetic linkage can be an important evolutionary force. Linkage generates interference interactions, by which simultaneously occurring mutations affect each other's chance of fixation. Here, we develop a comprehensive model of adaptive evolution in linked genomes, which integrates interference interactions between multiple beneficial and deleterious mutations into a unified framework. By an approximate analytical solution, we predict the fixation rates of these mutations, as well as the probabilities of beneficial and deleterious alleles at fixed genomic sites. We find that interference interactions generate a regime of emergent neutrality: all genomic sites with selection coefficients smaller in magnitude than a characteristic threshold have nearly random fixed alleles, and both beneficial and deleterious mutations at these sites have nearly neutral fixation rates. We show that this dynamic limits not only the speed of adaptation, but also a population's degree of adaptation in its current environment. We apply the model to different scenarios: stationary adaptation in a time-dependent environment and approach to equilibrium in a fixed environment. In both cases, the analytical predictions are in good agreement with numerical simulations. Our results suggest that interference can severely compromise biological functions in an adapting population, which sets viability limits on adaptive evolution under linkage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schiffels, Stephan UNSPECIFIED orcid.org/0000-0002-1017-9150 UNSPECIFIED Szoellosi, Gergely J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mustonen, Ville UNSPECIFIED orcid.org/0000-0002-7270-1792 UNSPECIFIED Laessig, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484816
DOI:	10.1534/genetics.111.132027
Journal or Publication Title:	Genetics
Volume:	189
Number:	4
Page Range:	S. 1361 - 1390
Date:	2011
Publisher:	GENETICS SOCIETY AMERICA
Place of Publication:	BETHESDA
ISSN:	1943-2631
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BENEFICIAL MUTATIONS; CLONAL INTERFERENCE; DELETERIOUS MUTATIONS; BACKGROUND SELECTION; MOLECULAR EVOLUTION; ADAPTATION; POPULATIONS; LINKAGE; HITCHHIKING; PATTERNS Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48481