Mareck, Ute, Guddat, Sven, Schwenke, Anne, Beuck, Simon, Geyer, Hans, Flenker, Ulrich, Elers, Jimmi, Backer, Vibeke ORCID: 0000-0002-7806-7219, Thevis, Mario and Schaenzer, Wilhelm (2011). Determination of salbutamol and salbutamol glucuronide in human urine by means of liquid chromatography-tandem mass spectrometry. Drug Test. Anal., 3 (11-12). S. 820 - 828. HOBOKEN: WILEY-BLACKWELL. ISSN 1942-7611

Full text not available from this repository.

Abstract

The determination of salbutamol and its glucuronide in human urine following the inhalative and oral administration of therapeutic doses of salbutamol preparations was performed by means of direct urine injection utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) and employing d3-salbutamol and d3-salbutamol glucuronide as internal standards. Unconjugated salbutamol was detected in all administration study urine samples. Salbutamol concentrations following inhalation were commonly (99%) below 1000?ng/ml whereas values after oral administration frequently (48%) exceeded this threshold.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mareck, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guddat, SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwenke, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beuck, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geyer, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flenker, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elers, JimmiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Backer, VibekeUNSPECIFIEDorcid.org/0000-0002-7806-7219UNSPECIFIED
Thevis, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaenzer, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-485723
DOI: 10.1002/dta.367
Journal or Publication Title: Drug Test. Anal.
Volume: 3
Number: 11-12
Page Range: S. 820 - 828
Date: 2011
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1942-7611
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DOPING CONTROLMultiple languages
Biochemical Research Methods; Chemistry, Analytical; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48572

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item