Universität zu Köln

Moesges, R., Nematian-Samani, M., Hellmich, M. and Shah-Hosseini, K. (2011). A meta-analysis of the efficacy of quinolone containing otics in comparison to antibiotic-steroid combination drugs in the local treatment of otitis externa. Curr. Med. Res. Opin., 27 (10). S. 2053 - 2061. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1473-4877

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Abstract

Background: The term otitis externa denotes the inflammation of the external auditory canal and can be treated locally in the form of monotherapy or a combination drug. Objective: The aim of the present meta-analysis was to compare the efficacy of an antibiotic-steroid combination drug with that of monotherapy. According to current data, a comparable investigation based on network analysis does not exist. Methods: After systematically searching the PubMed, Medline, Medpilot, Web of Science and Embase electronic databases, 12 relevant randomized, controlled, clinical studies were identified involving 2682 evaluable patients with regard to the cure rate and seven publications with 1251 microbiologically assessable patients. The collected data were compared directly and indirectly by means of network analysis. Results: The direct comparison showed a trend towards the superiority of the monotherapy containing quinolone. The network analysis verified this tendency and demonstrated that pure quinolone drugs can achieve a significantly higher cure rate (OR: 1.29; 95% CI: 1.06-1.57; p=0.01) and a significantly superior eradication rate (OR: 1.44; 95% CI: 1.03-2.02; p=0.03) compared to combination drugs not containing quinolone. We found substantial heterogeneity (with I-2 up to 88.7%) between studies, presumably due to treatments applied in varying frequency, thus bearing on compliance and outcome. Conclusion: With a level Ia evidence, this investigation validates the clinical benefit of quinolones as compared to classic combination drugs in the local treatment of acute otitis externa.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moesges, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nematian-Samani, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-487657
DOI:	10.1185/03007995.2011.616192
Journal or Publication Title:	Curr. Med. Res. Opin.
Volume:	27
Number:	10
Page Range:	S. 2053 - 2061
Date:	2011
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1473-4877
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B-NEOMYCIN-HYDROCORTISONE; POLYMYXIN-B; OXYTETRACYCLINE HYDROCORTISONE; TRIAL; CIPROFLOXACIN; SAFETY; SUSPENSION; THERAPY; ACETATE; AGENT Multiple languages Medicine, General & Internal; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48765