Milne, Roger L., Goode, Ellen L., Garca-Closas, Montserrat, Couch, Fergus J., Severi, Gianluca ORCID: 0000-0001-7157-419X, Hein, Rebecca, Fredericksen, Zachary, Malats, Nuria ORCID: 0000-0003-2538-3784, Pilar Zamora, M., Arias Perez, Jose Ignacio, Benitez, Javier, Doerk, Thilo, Schuermann, Peter, Karstens, Johann H., Hillemanns, Peter, Cox, Angela ORCID: 0000-0002-5138-1099, Brock, Ian W., Elliot, Graeme, Cross, Simon S., Seal, Sheila, Turnbull, Clare ORCID: 0000-0002-1734-5772, Renwick, Anthony, Rahman, Nazneen ORCID: 0000-0003-4376-0440, Shen, Chen-Yang, Yu, Jyh-Cherng, Huang, Chiun-Sheng ORCID: 0000-0002-6557-211X, Hou, Ming-Feng ORCID: 0000-0001-6030-9702, Nordestgaard, Borge G., Bojesen, Stig E., Lanng, Charlotte, Alnaes, Grethe Grenaker, Kristensen, Vessela, Borrensen-Dale, Anne-Lise, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Lambrechts, Diether ORCID: 0000-0002-3429-302X, Yesilyurt, Betul T., Floris, Giuseppe, Leunen, Karin, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Chang-Claude, Jenny, Wang-Gohrke, Shan, Radice, Paolo ORCID: 0000-0001-6298-4111, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Manoukian, Siranoush, Barile, Monica, Giles, Graham G., Baglietto, Laura ORCID: 0000-0002-8193-7529, John, Esther M., Miron, Alexander, Chanock, Stephen J., Lissowska, Jolanta ORCID: 0000-0003-2695-5799, Sherman, Mark E., Figueroa, Jonine D., Bogdanova, Natalia V., Antonenkova, Natalia N., Zalutsky, Iosif V., Rogov, Yuri I., Fasching, Peter A., Bayer, Christian M., Ekici, Arif B., Beckmann, Matthias W., Brenner, Hermann ORCID: 0000-0002-6129-1572, Mueller, Heiko, Arndt, Volker ORCID: 0000-0001-9320-8684, Stegmaier, Christa, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Mulligan, Anna Marie ORCID: 0000-0002-7239-5297, Mannermaa, Arto, Kataja, Vesa ORCID: 0000-0003-4846-4843, Kosma, Veli-Matti, Hartikainen, Jaana M., Meindl, Alfons, Heil, Joerg ORCID: 0000-0002-4684-9099, Bartram, Claus R., Schmutzler, Rita K., Thomas, Gilles D., Hoover, Robert N., Fletcher, Olivia ORCID: 0000-0001-9387-7116, Gibson, Lorna J., Silva, Isabel dos Santos, Peto, Julian, Nickels, Stefan, Flesch-Janys, Dieter, Anton-Culver, Hoda, Ziogas, Argyrios, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael ORCID: 0000-0003-4164-5561, Miller, Nicola, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Tollenaar, Rob A. E. M., Pharoah, Paul D. P., Dunning, Alison M., Pooley, Karen A., Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Jakubowska, Anna ORCID: 0000-0002-5650-0501, Lubinski, Jan ORCID: 0000-0003-2931-3003, Jaworska, Katarzyna, Durda, Katarzyna, Kang, Daehee ORCID: 0000-0003-4031-5878, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Kraft, Peter, Lindstrom, Sara, Chen, Xiaoqing, Beesley, Jonathan ORCID: 0000-0003-1942-325X, Hamann, Ute, Harth, Volker, Justenhoven, Christina, Winqvist, Robert, Pylkas, Katri ORCID: 0000-0002-2449-0521, Jukkola-Vuorinen, Arja, Grip, Mervi, Hooning, Maartje, Hollestelle, Antoinette ORCID: 0000-0003-1166-1966, Oldenburg, Rogier A., Tilanus-Linthorst, Madeleine, Khusnutdinova, Elza, Bermisheva, Marina, Prokofieva, Darya, Farahtdinova, Albina, Olson, Janet E., Wang, Xianshu, Humphreys, Manjeet K., Wang, Qin, Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587 and Easton, Douglas F. (2011). Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor-Positive, Lower Grade Breast Cancer. Cancer Epidemiol. Biomarkers Prev., 20 (10). S. 2222 - 2232. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7755

Full text not available from this repository.

Abstract

Background: The single-nucleotide polymorphism (SNP) 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease. We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium. Methods: Data were combined from 37 studies, including 40,972 invasive cases, 1,398 cases of ductal carcinoma in situ (DCIS), and 46,334 controls, all of white European ancestry, as well as 3,007 invasive cases and 2,337 controls of Asian ancestry. Associations overall and by tumor invasiveness and histopathology were assessed using logistic regression. Results: For white Europeans, the per-allele OR associated with 5p12-rs10941679 was 1.11 (95% CI = 1.08-1.14, P = 7 x 10(-18)) for invasive breast cancer and 1.10 (95% CI = 1.01-1.21, P = 0.03) for DCIS. For Asian women, the estimated OR for invasive disease was similar (OR 1.07, 95% CI = 0.99-1.15, P = 0.09). Further analyses suggested that the association in white Europeans was largely limited to progesterone receptor (PR)positive disease (per-allele OR = 1.16, 95% CI = 1.12-1.20, P = 1 x 10(-18) vs. OR = 1.03, 95% CI = 0.99-1.07, P = 0.2 for PR-negative disease; P-heterogeneity 2 x 10(-7)); heterogeneity by ER status was not observed (P = 0.2) once PR status was accounted for. The association was also stronger for lower grade tumors [per-allele OR (95% CI) 1.20 (1.14-1.25), 1.13 (1.09-1.16), and 1.04 (0.99-1.08) for grade 1, 2, and 3/4, respectively; Ptrend 5 x 10(-7)]. Conclusion: 5p12 is a breast cancer susceptibility locus for PR-positive, lower grade breast cancer. Impact: Multicenter fine-mapping studies of this region are needed as a first step to identifying the causal variant or variants. Cancer Epidemiol Biomarkers Prev; 20(10); 2222-31. (C) 2011 AACR.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Milne, Roger L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goode, Ellen L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garca-Closas, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Severi, GianlucaUNSPECIFIEDorcid.org/0000-0001-7157-419XUNSPECIFIED
Hein, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fredericksen, ZacharyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malats, NuriaUNSPECIFIEDorcid.org/0000-0003-2538-3784UNSPECIFIED
Pilar Zamora, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arias Perez, Jose IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benitez, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerk, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuermann, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karstens, Johann H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillemanns, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, AngelaUNSPECIFIEDorcid.org/0000-0002-5138-1099UNSPECIFIED
Brock, Ian W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elliot, GraemeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cross, Simon S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seal, SheilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turnbull, ClareUNSPECIFIEDorcid.org/0000-0002-1734-5772UNSPECIFIED
Renwick, AnthonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahman, NazneenUNSPECIFIEDorcid.org/0000-0003-4376-0440UNSPECIFIED
Shen, Chen-YangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yu, Jyh-CherngUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, Chiun-ShengUNSPECIFIEDorcid.org/0000-0002-6557-211XUNSPECIFIED
Hou, Ming-FengUNSPECIFIEDorcid.org/0000-0001-6030-9702UNSPECIFIED
Nordestgaard, Borge G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bojesen, Stig E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lanng, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alnaes, Grethe GrenakerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kristensen, VesselaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borrensen-Dale, Anne-LiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dite, Gillian S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apicella, CarmelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, Melissa C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambrechts, DietherUNSPECIFIEDorcid.org/0000-0002-3429-302XUNSPECIFIED
Yesilyurt, Betul T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Floris, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leunen, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sangrajrang, SuleepornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaborieau, ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McKay, JamesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chang-Claude, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang-Gohrke, ShanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radice, PaoloUNSPECIFIEDorcid.org/0000-0001-6298-4111UNSPECIFIED
Peterlongo, PaoloUNSPECIFIEDorcid.org/0000-0001-6951-6855UNSPECIFIED
Manoukian, SiranoushUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barile, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giles, Graham G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baglietto, LauraUNSPECIFIEDorcid.org/0000-0002-8193-7529UNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miron, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chanock, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lissowska, JolantaUNSPECIFIEDorcid.org/0000-0003-2695-5799UNSPECIFIED
Sherman, Mark E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueroa, Jonine D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bogdanova, Natalia V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonenkova, Natalia N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zalutsky, Iosif V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rogov, Yuri I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fasching, Peter A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayer, Christian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ekici, Arif B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckmann, Matthias W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brenner, HermannUNSPECIFIEDorcid.org/0000-0002-6129-1572UNSPECIFIED
Mueller, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arndt, VolkerUNSPECIFIEDorcid.org/0000-0001-9320-8684UNSPECIFIED
Stegmaier, ChristaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knight, Julia A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glendon, GordUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulligan, Anna MarieUNSPECIFIEDorcid.org/0000-0002-7239-5297UNSPECIFIED
Mannermaa, ArtoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kataja, VesaUNSPECIFIEDorcid.org/0000-0003-4846-4843UNSPECIFIED
Kosma, Veli-MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartikainen, Jaana M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heil, JoergUNSPECIFIEDorcid.org/0000-0002-4684-9099UNSPECIFIED
Bartram, Claus R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, Gilles D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoover, Robert N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fletcher, OliviaUNSPECIFIEDorcid.org/0000-0001-9387-7116UNSPECIFIED
Gibson, Lorna J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silva, Isabel dos SantosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peto, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickels, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flesch-Janys, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anton-Culver, HodaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziogas, ArgyriosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawyer, ElinorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomlinson, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerin, MichaelUNSPECIFIEDorcid.org/0000-0003-4164-5561UNSPECIFIED
Miller, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Marjanka K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broeks, AnnegienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van't Veer, Laura J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tollenaar, Rob A. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, Paul D. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, Alison M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pooley, Karen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marme, FrederikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneeweiss, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohn, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burwinkel, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDorcid.org/0000-0002-5650-0501UNSPECIFIED
Lubinski, JanUNSPECIFIEDorcid.org/0000-0003-2931-3003UNSPECIFIED
Jaworska, KatarzynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Durda, KatarzynaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kang, DaeheeUNSPECIFIEDorcid.org/0000-0003-4031-5878UNSPECIFIED
Yoo, Keun-YoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noh, Dong-YoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahn, Sei-HyunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunter, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hankinson, Susan E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraft, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindstrom, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, XiaoqingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beesley, JonathanUNSPECIFIEDorcid.org/0000-0003-1942-325XUNSPECIFIED
Hamann, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harth, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Justenhoven, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winqvist, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pylkas, KatriUNSPECIFIEDorcid.org/0000-0002-2449-0521UNSPECIFIED
Jukkola-Vuorinen, ArjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grip, MerviUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, MaartjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hollestelle, AntoinetteUNSPECIFIEDorcid.org/0000-0003-1166-1966UNSPECIFIED
Oldenburg, Rogier A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tilanus-Linthorst, MadeleineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khusnutdinova, ElzaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bermisheva, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prokofieva, DaryaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farahtdinova, AlbinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olson, Janet E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, XianshuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Humphreys, Manjeet K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, QinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chenevix-Trench, GeorgiaUNSPECIFIEDorcid.org/0000-0002-1878-2587UNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-488347
DOI: 10.1158/1055-9965.EPI-11-0569
Journal or Publication Title: Cancer Epidemiol. Biomarkers Prev.
Volume: 20
Number: 10
Page Range: S. 2222 - 2232
Date: 2011
Publisher: AMER ASSOC CANCER RESEARCH
Place of Publication: PHILADELPHIA
ISSN: 1538-7755
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; CONFER SUSCEPTIBILITY; COMMON VARIANTS; SUBTYPES; ALLELES; RISKMultiple languages
Oncology; Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48834

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