Universität zu Köln

Liakopoulos, Oliver J., Hristov, Nikola, Buckberg, Gerald D., Triana, Jonathan, Trummer, Georg ORCID: 0000-0001-5664-8971 and Allen, Bradley S. (2011). Resuscitation after prolonged cardiac arrest: effects of cardiopulmonary bypass and sodium-hydrogen exchange inhibition on myocardial and neurological recovery. Eur. J. Cardio-Thorac. Surg., 40 (4). S. 978 - 985. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1010-7940

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Abstract

Objective: To determine if cardiopulmonary bypass (CPB), together with inhibition of the sodium-hydrogen exchanger (NHE), limits myocardial and neurological injury and improves recovery after prolonged (unwitnessed) cardiac arrest (CA), as NHE inhibition improved recovery after deep hypothermic circulatory arrest. Methods: Twenty-seven pigs (31-39 kg) underwent 15 min of prolonged (no-flow) CA followed by 10 min of cardiopulmonary resuscitation-advanced life support (CPR-ALS). Subjects with restoration of spontaneous circulation (ROSC) during CPR-ALS received either no drug (n = 6) or an inhibitor of the NHE (HOE-642; n = 5). In the 16 unsuccessfully resuscitated animals, peripheral normothermic CPB was instituted, and either no drug (n = 9) or similar HOE-642 (n = 7) therapy started. Hemodynamic data, a species-specific neurological deficit score (0 = normal to 500 = brain death), and mortality were recorded at 24 h, and biochemical variables of organ injury measured. Results: CPR-ALS restored ROSC in 41% (11/27) of animals, but was unsuccessful in 59% (16/27) that required CPB. Without CPB, HOE-642 increased cardiac index and decreased vascular resistance; with CPB, HOE-642 caused higher pump flows (3.4 +/- 0.6 l min(-1) m(-2) vs 2.5 +/- 0.7 l min(-1) m(-2); p < 0.001) and higher post-arrest cardiac index; but animals required more vasopressors (p = 0.019) from drug-induced vasodilation. No differences between biochemical markers of oxidative and organ injury and overall 24-h mortality (20%) were found between groups. Neurological score was improved at 24 h compared with 4 h only after HOE-642 treatment with (150 +/- 34 vs 220 +/- 43; p = 0.003) or without CPB (162 +/- 39 vs 238 +/- 48; p <= 0.001), but failed to reach statistical difference with respect to the untreated group. Conclusions: CPB is an effective resuscitative tool to treat prolonged CA but there is limited improvement of neurological function. NHE inhibition augments cardiac and neurological function, but its effect was less pronounced than in other studies. (C) 2011 Published by Elsevier B. V. on behalf of European Association for Cardio-Thoracic Surgery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liakopoulos, Oliver J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hristov, Nikola UNSPECIFIED UNSPECIFIED UNSPECIFIED Buckberg, Gerald D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Triana, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Trummer, Georg UNSPECIFIED orcid.org/0000-0001-5664-8971 UNSPECIFIED Allen, Bradley S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488400
DOI:	10.1016/j.ejcts.2011.02.002
Journal or Publication Title:	Eur. J. Cardio-Thorac. Surg.
Volume:	40
Number:	4
Page Range:	S. 978 - 985
Date:	2011
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1010-7940
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HYPOTHERMIC CIRCULATORY ARREST; DEATH; CARIPORIDE; SURGERY; BRAIN Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48840