Universität zu Köln

Onur, Ozgur A., Piefke, Martina, Lie, Chuh-Hyoun, Thiel, Christiane M. and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2011). Modulatory Effects of Levodopa on Cognitive Control in Young but not in Older Subjects: A Pharmacological fMRI Study. J. Cogn. Neurosci., 23 (10). S. 2797 - 2811. CAMBRIDGE: MIT PRESS. ISSN 1530-8898

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Abstract

Older individuals show decline of prefrontal cortex (PFC) functions which may be related to altered dopaminergic neurotransmission. We investigated the effects of aging and dopaminergic stimulation in 15 young and 13 older healthy subjects on the neural correlates of interference control using fMRI. In a double-blind, placebo-controlled within-subject design, subjects were measured after levodopa (100 mg) or placebo administration. In each session, subjects performed a visual-spatial interference task based on a Stroop/Simon-like paradigm. Across age groups, interference (incongruent relative to congruent trials) was associated with activations in the presupplementary motor area, ACC, and intra-parietal cortex. Increased interference was found behaviorally in older volunteers. Differential activation in left dorsolateral PFC in young subjects and bilateral PFC activity in older subjects was observed to be associated with interference control. Performance deteriorated under levodopa only in young subjects. This was accompanied by an increase of neural activity in ACC (p < .05; small-volume correction for multiple comparisons). Worsening of performance under levodopa in young subjects and the associated effect on ACC may indicate that overstimulation of the dopaminergic system compromises interference control. This supports the inverted-U-shaped model of neurotransmitter action.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Onur, Ozgur A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Piefke, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lie, Chuh-Hyoun UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiel, Christiane M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488513
DOI:	10.1162/jocn.2011.21603
Journal or Publication Title:	J. Cogn. Neurosci.
Volume:	23
Number:	10
Page Range:	S. 2797 - 2811
Date:	2011
Publisher:	MIT PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1530-8898
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AGE-RELATED-CHANGES; ATTENTIONAL CONTROL; PREFRONTAL FUNCTION; DOPAMINE SYNTHESIS; NEURAL MECHANISMS; STROOP TASK; HUMAN BRAIN; MEMORY; INTERFERENCE; RECEPTORS Multiple languages Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48851