Universität zu Köln

Kukolja, J., Klingmueller, D., Maier, W., Fink, G. R. and Hurlemann, R. (2011). Noradrenergic-glucocorticoid modulation of emotional memory encoding in the human hippocampus. Psychol. Med., 41 (10). S. 2167 - 2177. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-8978

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Abstract

Background. Current rodent models emphasize the joint action of the stress mediators noradrenaline (NE) and cortisol (CORT) in conferring a memory advantage of emotional over neutral stimuli. Method. Using a pharmacological strategy of tackling this stress-related mechanism to enhance human episodic (autobiographical) memory, we measured amygdala-hippocampal responses during encoding of emotional and neutral stimuli with functional magnetic resonance imaging in 51 healthy subjects under four pharmacological conditions in a double-blind parallel group design: (i) placebo; (ii) the NE-reuptake inhibitor reboxetine (4 mg); (iii) hydrocortisone (synthetic CORT) (30 mg); or (iv) both agents in combination. Results. Differential drug effects were found in the left hippocampus, whereas hydrocortisone alone selectively decreased hippocampal responses to emotional relative to neutral stimuli, reboxetine potentiated hippocampal responses to these stimuli. Importantly, the inhibitory influence of hydrocortisone was reversed by co-administration of reboxetine. Conclusions. Our results imply that stress levels of CORT alone attenuate hippocampal responses to emotional stimuli, an effect possibly related to a regulatory negative feedback loop. However, when simultaneously elevated to stress levels, NE and CORT act together to synergistically enhance hippocampal activity during encoding of emotional stimuli, a mechanism that may turn maladaptive under circumstances of traumatic stress.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kukolja, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klingmueller, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hurlemann, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-488606
DOI:	10.1017/S0033291711000183
Journal or Publication Title:	Psychol. Med.
Volume:	41
Number:	10
Page Range:	S. 2167 - 2177
Date:	2011
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1469-8978
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN AMYGDALA; STRESS; ACTIVATION; ENHANCEMENT; INHIBITION; RESPONSES; STIMULI; AMNESIA; CORTEX; YOUNG Multiple languages Psychology, Clinical; Psychiatry; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48860