Universität zu Köln

Ukena, Christian, Mahfoud, Felix, Kindermann, Ingrid, Barth, Christine, Lenski, Matthias, Kindermann, Michael, Brandt, Mathias C., Hoppe, Uta C., Krum, Henry, Esler, Murray, Sobotka, Paul A. and Boehm, Michael (2011). lCardiorespiratory Response to Exercise After Renal Sympathetic Denervation in Patients With Resistant Hypertension. J. Am. Coll. Cardiol., 58 (11). S. 1176 - 1183. NEW YORK: ELSEVIER SCIENCE INC. ISSN 0735-1097

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Abstract

Objectives This study sought to investigate the effects of interventional renal sympathetic denervation (RD) on cardiorespiratory response to exercise. Background RD reduces blood pressure at rest in patients with resistant hypertension. Methods We enrolled 46 patients with therapy-resistant hypertension as extended investigation of the Symplicity HTN-2 (Renal Denervation With Uncontrolled Hypertension) trial. Thirty-seven patients underwent bilateral RD and 9 patients were assigned to the control group. Cardiopulmonary exercise tests were performed at baseline and 3-month follow-up. Results In the RD group, compared with baseline examination, blood pressure at rest and at maximum exercise after 3 months was significantly reduced by 31 +/- 13/9 +/- 13 mm Hg (p < 0.0001) and by 21 +/- 20/5 +/- 14 mm Hg (p < 0.0001), respectively. Achieved work rate increased by 5 +/- 13 W (p = 0.029) whereas peak oxygen uptake remained unchanged. Blood pressure 2 min after exercise was significantly reduced by 29 +/- 17/8 +/- 15 mm Hg (p < 0.001 for systolic blood pressure; p = 0.002 for diastolic blood pressure). Heart rate at rest decreased after RD (4 +/- 11 beats/min; p = 0.028), whereas maximum heart rate and heart rate increase during exercise were not different. Heart rate recovery improved significantly by 4 +/- 7 beats/min after renal denervation (p = 0.009). In the control group, there were no significant changes in blood pressure, heart rate, maximum work rate, or ventilatory parameters after 3 months. Conclusions RD reduces blood pressure during exercise without compromising chronotropic competence in patients with resistant hypertension. Heart rate at rest decreased and heart rate recovery improved after the procedure. (Renal Denervation With Uncontrolled Hypertension; [ Symplicity HTN-2]; NCT00888433) (J Am Coll Cardiol 2011; 58: 1176-82) (C) 2011 by the American College of Cardiology Foundation

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ukena, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahfoud, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Kindermann, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Barth, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenski, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kindermann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandt, Mathias C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Uta C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krum, Henry UNSPECIFIED UNSPECIFIED UNSPECIFIED Esler, Murray UNSPECIFIED UNSPECIFIED UNSPECIFIED Sobotka, Paul A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-489193
DOI:	10.1016/j.jacc.2011.05.036
Journal or Publication Title:	J. Am. Coll. Cardiol.
Volume:	58
Number:	11
Page Range:	S. 1176 - 1183
Date:	2011
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	0735-1097
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTOLIC BLOOD-PRESSURE; MIDDLE-AGED MEN; HEART-RATE RECOVERY; VENTILATORY EFFICIENCY; CONTROLLED-TRIAL; PREDICTOR; MORTALITY; FAILURE; ASSOCIATION; OUTCOMES Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48919